肥厚型梗阻性心肌病的治疗新进展

New progress in the treatment of hypertrophic obstructive cardiomyopathy

肥厚型心肌病是一种基因遗传病,人群发病率高;其中肥厚型梗阻性心肌病危害大,除引起胸痛、晕厥等临床症状外,严重者可致猝死。随着对发病机制研究的深入,关于流出道梗阻的药物和非药物治疗已取得很大进展,如Mavecamten精准生物学药物治疗和心尖部经皮心肌内室间隔射频消融术等。本文结合最新相关研究,对肥厚型梗阻性心肌病的药物治疗、介入治疗、射频消融治疗及基因治疗等方面进行系统阐述,以期增进对该病治疗和研究的认识。

Hypertrophic cardiomyopathy is a genetic disease,high incidence in the population.Among them,hypertrophic obstructive cardiomyopathy is harmful,in addition to causing chest pain,syncope,and other clinical symptoms,severe cases can cause sudden death.With the further study of the pathogenesis,much progress has been made in the treatment of outflow tract obstruction,both pharmacological and non-pharmacological,such as Mavecamten precision biology drug therapy and apical percutaneous cardiac interventricular radiofrequency ablation.Combined with the latest relevant research,in this paper,drug therapy,interventional therapy,radiofrequency ablation,and gene therapy of hypertrophic obstructive cardiomyopathy were systematically described,in order to improve the understanding of the treatment and research of the disease.