角膜接触镜相关干眼的研究进展

Research advances in contact lens-associated dry eye

干眼是除屈光不正外最常见的眼科疾病,可极大影响患者的工作和生活,已成为我国重要的公共卫生问题。配戴角膜接触镜(CL)被认为是干眼的危险因素之一。研究发现CL配戴人群干眼的发病率较健康人群高,配戴CL会导致或加速干眼的发生。2017年国际泪膜与眼表协会首次将角膜接触镜相关干眼(CLADE)纳入医源性干眼的范畴,其重要性可见一斑。即往眼科医师多关注于配戴CL引起的角膜炎等严重并发症,对更常见的CLADE重视不够,认识也不足。本文就CLADE的流行病学、发病机制、诊断、预防和治疗的相关研究进行综述。

Dry eye is the most common disease in ophthalmic clinics besides refractive error,which seriously affects the life quality of patients and has become an important public health problem in China.Dry eye as a kind of multifactorial disease can be induced or accelerated by contact lens wear,which is considered as one of the risk factors of dry eye.Studies have shown that the incidence of dry eye is higher in contact lens wearers than in normal people.In 2017,the Tear Film and Ocular Surface Society included contact lens-associated dry eye(CLADE)in the iatrogenic dry eye for the first time,and its importance is evident.However,ophthalmologists mostly used to focus on serious complications such as keratitis caused by contact lens wear,and CLADE has not been well valued and understood.This article reviews the latest studies on the epidemiology,pathogenesis,diagnosis,prevention,and treatment of CLADE.