牙本质作为骨修复材料的研究进展

Research progress on the dentin bone repair material

各种原因造成的口腔硬组织缺损给口腔修复带来了极大的困难。寻找一种具有良好骨传导性、骨诱导性、生物相容性和可吸收性的新型骨修复材料是近年来的研究热点。牙本质是一种新型骨修复材料,来源广泛,可取自临床中拔除的废用牙或阻生齿。牙本质与牙槽骨有相同的组织学来源,理化性质相似,且含有大量的骨活性因子,用作骨修复材料具有其他材料无法比拟的天然优势,近年来已有多个动物实验与临床研究表明其成骨效果良好。本文就牙本质材料的成骨机制、处理方法及临床应用等进展进行综述,为临床牙本质作为骨修复材料的应用提供参考。

Various events can cause oral bone loss,which results in the dysfunction of oral and maxillofacial area and difficulties in oral rehabilitation.Therefore,a new osteogenic material possesses excellent osteoconductivity,osteoinductivity,biocompatibility,and absorbability.Dentin has been widely explored as a novel bone repair material,which can be obtained from a wide range of sources such as waste or impacted teeth.It shares the same neural crest embryonic origin with a maxillofacial bone and resembles each other in physiochemical characteristics,which give dentin a natural advantage to promote bone regeneration.Dentin is also a storage of various bioactive molecules and growth factors.A great number of animal studies have shown that dentin can induce bone regeneration.Numerous successful clinical outcomes of dentin have been reported when it is used in a variety of therapies.This review aims to introduce the bone formation mechanism,preparation procedure,and clinical application of dentin bone repair material and provide further theoretical basis for its use.