内皮发育调节基因-1与牙周炎相关性的研究进展

Research progress on the relationship between new anti-inflammatory factor developmental endothelial locus-1 and periodontitis

牙周炎是慢性感染性疾病之一,菌斑微生物及其产物作为牙周炎始动因子不仅可以直接破坏牙周组织,而且可通过影响宿主免疫反应间接影响牙周炎的进程。内皮发育调节基因-1(DEL-1)是1种分泌型多结构域蛋白,作为新型抗炎因子可调节宿主炎症反应的不同阶段。研究表明,DEL-1不仅在牙周炎炎症起始阶段参与调节中性粒细胞的趋化募集,而且可调节免疫反应诱导炎症消退和抑制牙槽骨吸收、促进新骨形成。本文就新型抗炎因子DEL-1参与调控牙周炎相关性研究作一综述。

Periodontitis is a chronic infectious disease.As initial factors of periodontitis,plaque microorganisms and their products can destroy periodontal tissue directly and indirectly affect the process of periodontitis by affecting host immune response.Developmental endothelial locus-1(DEL-1)is a secretory multi-domain protein that regulates different stages of host inflammatory response according to its expression location.DEL-1 is involved in the regulation of neutrophil recruitment at the initial stage of periodontitis and can induce inflammation resolution,which can inhibit alveolar bone resorption and promote new bone formation.This article reviews the research on the role of new anti-inflammatory factor DEL-1 in the regulation of periodontitis.