摘要
铁死亡(ferroptosis)是具有铁依赖性的一种新的程序性细胞死亡方式。铁死亡的主要特征包括脂质活性氧积累、铁离子积累和脂质过氧化。铁死亡的主要机制和信号通路较为复杂,与胱氨酸/谷氨酸逆向转运体、谷胱甘肽过氧化物酶4、铁死亡抑制蛋白1、二氢乳清酸脱氢酶等密切相关。本文就现有铁死亡的调控机制进行整理,并对铁死亡与肿瘤、非酒精性脂肪肝、帕金森综合征和充血性心力衰竭等疾病的研究进展进行论述。
Ferroptosis is an iron-dependent novel type of programmed cell death.The main features of ferroptosis include lipid reactive oxygen accumulation,iron accumulation and lipid peroxidation.The main mechanisms and signal pathways of ferroptosis are complex and closely related to cystine/glutamate antiporter system,glutathione peroxidase 4,ferroptosis suppressor protein 1,and dihydroorotate dehydrogenase.This review summarizes the current regulatory mechanisms of ferroptosis and discusses the research progress of ferroptosis in tumors,non-alcoholic fatty liver disease,Parkinson's disease,and congestive heart failure.
作者
张亮
廖勇群
夏秦川
周诗侗
李小丽
ZHANG Liang;LIAO Yongqun;XIA Qinchuan;ZHOU Shitong;LI Xiaoli(Department of Pharmacology,College of Pharmacy,Chongqing Medical University,Chongqing 400016,China;Chongqing Key Laboratory of Drug Metabolism,Chongqing 400016,China;Fuan Pharmaceutical Group Chongqing Bosen Pharmaceutical CO.LTD,Chongqing 401221,China;Department of Otolaryngology Head and Neck Surgery,Chongqing General Hospital,University of Chinese Academy of Sciences,Chongqing 400014,China)
出处
《中国临床药理学与治疗学》
CAS
CSCD
2022年第2期227-234,共8页
Chinese Journal of Clinical Pharmacology and Therapeutics
基金
重庆市自然科学基金面上项目(cstc2020jcyjmsxm X0223)
重庆市人民医院医学科技创新基金面上项目(Y2020MSXM16)
关键词
铁死亡
铁离子代谢
脂质过氧化
癌症
非酒精性脂肪肝
ferroptosis
iron metabolism
lipid peroxidation
cancer
non-alcoholic fatty liver disease
