阿司匹林联合人免疫球蛋白静脉注射治疗川崎病患儿的效果

Effect of aspirin combined with intravenous human immunoglobulin in the treatment of Kawasaki disease in children

目的:分析阿司匹林、人免疫球蛋白联合治疗川崎病患者的临床疗效及对患儿血液指标、免疫功能的影响。方法:回顾性分析青海省心脑血管病专科医院2019年1月至2021年6月收治的104例川崎病患者,按治疗方法分为对照组(n=52)与观察组(n=52)。对照组采用阿司匹林治疗,观察组采用阿司匹林+人免疫球蛋白治疗。观察两组临床疗效,比较血液指标、免疫功能变化。结果:观察组患儿冠状动脉扩张率为3.85%,低于对照组的23.08%,且发热时间短于对照组,差异均有统计学意义(均P<0.05)。两组患儿的血小板上升时间、血小板上升至正常时间、血小板止血时间、住院时间差异均无统计学意义(均P>0.05);观察组患儿的血小板达峰值时间显著短于对照组(P<0.05);观察组患儿治疗后的白细胞计数(white blood cells,WBC)、C反应蛋白(C-reaction protein,CPR)水平均低于对照组,ESR、PLT水平均显著高于对照组(均P<0.05)。治疗前,两组CD3+、CD4+等指标值差异均无统计学意义(均P>0.05);治疗后,观察组上述免疫功能指标值均高于对照组,差异均有统计学意义(均P<0.05)。两组患儿不良反应发生率差异无统计学意义(P>0.05)。结论:阿司匹林联合人免疫球蛋白治疗川崎病疗效确切,能够降低冠状动脉扩张率,改善血液指标及免疫功能,值得临床推广。

Objective:To analyze the effect of aspirin and human immunoglobulin combined therapy for Kawasaki disease.Methods:A retrospective analysis was performed on 104 patients with Kawasaki disease admitted to our hospital from January 2019 to June 2021,who were divided into a control group(n=52)and an observation group(n=52)according to treatment methods.The control group received aspirin treatment,the observation group received aspirin+human immunoglobulin treatment.The clinical efficacy,the blood indicators and immune function changes were observed.Results:The coronary artery dilation rate in the observation group was 3.85%which was lower than that in the control group(23.08%),and fever time was shorter than that in the control group,and the difference between the 2 groups was statistically significant(P<0.05).There were no significant differences in platelet rise time,platelet rise to normal time,platelet hemostasis time and hospital stay ratio between the 2 groups(P>0.05).The peak time of platelet in observation group was significantly shorter than that in the control group(P<0.05).White blood cells(WBC)and C-reaction protein(CPR)in the observation group were lower than those in the control group after the treatment,and platelet(PLT)and erythrocyte sedimentation rate(ESR)indexes were significantly higher than those in the control group(P<0.05).Before the treatment,there was no significant difference in CD3+,CD4+and other indexes between the 2 groups(P>0.05).After the treatment,the above immune function indexes in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion:Aspirin combined with human immunoglobulin in the treatment of Kawasaki disease is effective,which can reduce the coronary artery dilation rate,and improve blood indicators and immune function level.