地西泮联合硫酸镁治疗妊娠期高血压的效果评价及对患者睡眠质量影响分析

Evaluation of Diazepam Combined with Magnesium Sulfate in the Treatment of Gestational Hypertension and Its Effect on Sleep Quality

目的:分析地西泮与硫酸镁治疗妊娠期高血压患者的疗效及对患者睡眠质量的影响。方法:选取2020年1月至2021年1月宁化县总医院收治的妊娠期高血压患者84例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组42例。2组患者均给予拉贝洛尔片进行常规治疗,观察组加用地西泮与硫酸镁治疗,对照组加用硫酸镁治疗,分析2组的疗效、焦虑情绪、睡眠质量、血压、24 h尿蛋白与药物不良反应。结果:治疗后,观察组疗效高于对照组,汉密尔顿焦虑评分(HAMA)、匹兹堡睡眠质量指数(PSQI)评分均低于对照组;观察组收缩压、舒张压、24 h尿蛋白等指标均低于对照组;以上指标2组比较,差异均有统计学意义(均P<0.05)。观察组药物不良反应发生率低于对照组;观察组早产、产后出血、新生儿宫内窘迫等不良分娩结局发生率均低于对照组,2组比较差异均有统计学意义(均P<0.05)。观察组阴道分娩率、血清白血病抑制因子、β绒毛膜促性腺激素等指标均高于对照组,2组比较差异有统计学意义(均P<0.05)。结论:妊娠期高血压采用地西泮与硫酸镁治疗,可更有效缓解患者的焦虑情绪、提升睡眠质量,还可有效降压、减少24 h尿蛋白含量,且药物不良反应风险低,可推广应用。

Objective:To analyze the efficacy of diazepam and magnesium sulfate in the treatment of pregnancy induced hypertension and its effect on sleep quality.Methods:A total of 84 patients with gestational hypertension treated in Ninghua General Hospital from January 2020 to January 2021 were selected as the research objects.They were randomly divided into control group and observation group according to random number table method,with 42 cases in each group.The patients in both groups were given labetalol tablets for routine treatment.The observation group was treated with diazepam and magnesium sulfate,and the control group was treated with magnesium sulfate.The efficacy,anxiety,sleep quality,blood pressure,24 h urinary protein and adverse drug reactions of the two groups were analyzed.Results:After treatment,the curative effect of the observation group was higher than that of the control group,and the scores of Hamilton Anxiety Score(HAMA)and Pittsburgh Sleep Quality Index(PSQI)were lower than those of the control group;Systolic blood pressure,diastolic blood pressure and 24 h urinary protein in the observation group were lower than those in the control group.There were significant differences in the above indexes between the two groups(Ps<0.05).The incidence of adverse drug reactions in the observation group was lower than that in the control group.The incidence of adverse delivery outcomes such as preterm delivery,postpartum hemorrhage and neonatal intrauterine distress in the observation group were lower than those in the control group.There were significant differences between the two groups(Ps<0.05).Vaginal delivery rate,serum leukemia inhibitory factorβchorionic gonadotropin and other indexes were higher than those in the control group.There was significant difference between the two groups(Ps<0.05).Conclusion:Diazepam and magnesium sulfate in the treatment of gestational hypertension can more effectively alleviate the anxiety of patients,improve sleep quality,effectively reduce blood pressure,reduce the content of 24 h urinary protein,and have a low risk of adverse drug reactions,which can be popularized.