醒脑静联合盐酸纳洛酮治疗脑出血后昏迷患者的临床效果及睡眠质量评价分析

Clinical Effect and Sleep Quality Evaluation of Xingnaojing Combined with Naloxone Hydrochloride in the Treatment of Coma Patients after Cerebral Hemorrhage

目的:探析脑出血后昏迷患者醒脑静联合盐酸纳洛酮的应用效果及其对睡眠质量的影响。方法:选取2017年1月至2019年12月平原县第一人民医院收治的脑出血后昏迷患者80例作为研究对象,按照治疗方法分为对照组和观察组,每组40例。对照组给予盐酸纳洛酮治疗,观察组给予醒脑静治疗,观察2组患者临床治疗效果,包括睡眠质量、脑血肿量、预后、昏迷持续时间以及治疗有效率。结果:观察组治疗总有效率为92.50%,明显高于对照组的72.50%,差异有统计学意义(P<0.05);治疗后,观察组匹兹堡睡眠质量指数(PSQI)评分与脑血肿量分别为(7.26±1.23)分、(18.56±3.22)mL,低于对照组的(10.65±1.22)分、(26.53±4.21)mL,而格拉斯哥昏迷指数(GCS)评分为(14.65±1.41)分,高于对照组的(9.25±1.22)分,昏迷持续时间为(7.26±2.31)d,短于对照组的(13.26±3.26)d,差异均有统计学意义(均P<0.05)。结论:醒脑静联合盐酸纳洛酮在脑出血后昏迷患者治疗中的应用,能够降低患者脑血肿量,改善患者睡眠质量,缩短患者昏迷时间,显著改善其预后,显著提高临床治疗效果,具有临床推广的应用价值。

Objective:To explore the effect of Xingnaojing combined with naloxone hydrochloride in the treatment of coma patients after cerebral hemorrhage and its effect on sleep quality.Methods:A total of 80 patients with coma after cerebral hemorrhage admitted to the First People′s Hospital of Pingyuan County from January 2017 to December 2019 were selected as the research objects,and they were divided into the control group and the observation group according to treatment,with 40 cases in each group.Naloxone hydrochloride and Xingnaojing were given sequentially.The clinical treatment effects of the two groups were observed,including sleep quality,cerebral hematoma volume,prognosis,coma duration and treatment efficiency.Results:The GSC score(14.65±1.41)was higher than that of the control group(9.25±1.22),and the duration of coma(7.26±2.31)d was shorter than that of the control group(13.26±3.26)d(Ps<0.05).The total effective rate of treatment in the observation group was 92.50%,which was significantly higher than 72.50%in the control group(Ps<0.05).After treatment,the Pittsburgh Sleep Quality Index(PSQI)score and cerebral hematoma volume in the observation group were(7.26±1.23)points and(18.56±3.22)mL,respectively,which were lower than(10.65±1.22)points and(26.53±4.21)mL in the control group.While the Glasgow Coma Scale(GCS)score was(14.65±1.41)points,which was higher than that of the control group(9.25±1.22)points,and the coma duration was(7.26±2.31)days,which was shorter than that of the control group(13.26±3.26)days,the difference was statistically significant(Ps<0.05).Conclusion:The application of Xingnaojing combined with Naloxone hydrochloride in the treatment of coma patients after intracerebral hemorrhage which can reduce the amount of cerebral hematoma,improve the sleep quality of patients,shorten the coma time of patients,significantly improve the prognosis,significantly improve the clinical treatment effect,has the value of clinical application.