七味都气丸加味对稳定期COPD患者运动耐量及生命质量的影响

Effect of Qiweiduqi Pill Supplementation on Exercise Tolerance and Quality of Life in Stable COPD Patients

目的:探讨七味都气丸加味对稳定期慢性阻塞性肺疾病(COPD)患者运动耐量及生命质量的影响。方法:选取2018年8月至2019年8月福州市中医院呼吸科收治的稳定期COPD患者80例作为研究对象,按照随机数字表法分为观察组和对照,每组40例。对照组给予常规治疗,观察组在对照组治疗基础上加入七味都气丸加味治疗。比较2组患者治疗前后6分钟步行距离(6MWD)、第一秒用力呼气容积(FEV1)、用力肺活量(FVC),采用改良英国医学研究委员会呼吸困难(mMRC)量表比较2组患者呼吸变化,采用圣乔治呼吸问卷(SGRQ)比较2组患者呼吸变化,采用睡眠状况自评量表(SRSS)比较2组患者睡眠情况。结果:治疗前,2组的6MWD、FEV1、FVC、mMRC评分、SGRQ、SRSS评分比较,差异无统计学意义(均P>0.05),治疗后,2组的6MWD、FEV1、FVC与治疗前比较都有增高,观察组显著高于对照组,SGRQ评分、mMRC、SRSS评分治疗前比较有所下降,观察组下降幅度显著高于对照组,2组比较差异均有统计学意义(均P<0.05)。结论:相对于常规治疗,七味都气丸加味治疗稳定期COPD可以有效提高患者运动耐量及生命质量。

Objective:To investigate the effect of Qiweiduqi pill on exercise tolerance and quality of life of patients with stable chronic obstructive pulmonary disease(COPD).Methods:A total of 80 stable COPD patients admitted to the Respiratory Department of Fuzhou Hospital of Traditional Chinese Medicine from August 2018 to August 2019 were selected as the research objects,and were divided into observation group and control group according to the random number table method,with 40 patients in each group.The control group was given conventional treatment,and the observation group was treated with Qiweiduqi pill.6 Minutes Walking Distance(6MWD),forced expiratory volume in the first second(FEV1)and forced vital capacity(FVC)were compared between 2 groups before and after treatment.The Respiratory changes of the two groups were compared using the Modified Medical Research Council(mMRC),and St.George′s Respiratory Questionnaire(SGRQ),and Self-rating Scale of Sleep(SRSS)was used to compare the sleep status of patients in the two groups.Results:Before treatment,there were no statistically significant differences in 6MWD,FEV1,FVC,mMRC score,SGRQ and SRSS score between the two groups(Ps>0.05).After treatment,6MWD,FEV1 and FVC in the two groups increased compared with before treatment,and the observation group was significantly higher than the control group.SGRQ score,mMRC score and SRSS score decreased before treatment,and the decrease rate in the observation group was significantly higher than that in the control group,with statistically significant differences between the two groups(Ps<0.05).Conclusion:Compared with conventional treatment,Qiweiduqi pill can effectively improve exercise tolerance and quality of life of patients with stable COPD.