脑梗死合并阻塞性睡眠呼吸暂停综合征患者血栓形成的相关因素分析

Analysis of Related Factors of Thrombosis in Patients with Cerebral Infarction Complicated with Obstructive Sleep Apnea Syndrome

目的:分析脑梗死(CI)合并阻塞性睡眠呼吸暂停综合征(OSAS)患者血栓发生的相关因素。方法:选取2018年11月至2019年11月福建医科大学附属三明第一医院收治的脑梗死合并阻塞性睡眠呼吸暂停综合征患者37例作为观察组研究对象,阻塞性睡眠呼吸暂停综合征患者排除脑梗死患者37例作为对照A组,脑梗死患者排除阻塞性睡眠呼吸暂停综合征患者37例作为对照B组。检测并分析3组体质量指数、内皮素(ET)指数、多导睡眠监测(PSG)指标、血液流变学指标。结果:对照A组、对照B组与观察组体质量指数比较,差异无统计学意义(P>0.05)。观察组内皮素指数(132.67±38.58)pg/mL,远高于对照A组的(77.39±43.51)pg/mL以及对照B组的(76.24±42.87)pg/mL,差异有统计学意义(均P<0.05)。观察组呼吸暂停通气指数(AHI)为62.34±13.28、呼吸最长暂停时间(LAT)为(87.39±18.34)s,分别高于对照A组与对照B组(均P<0.05),但最低脉氧饱和度(LSpO2)(53.36±1.29)%,低于对照A组与对照B组,差异有统计学意义(均P<0.05)。观察组全血黏滞度(WBV)(2.26±0.39)mPa·s、纤维蛋白原(FIB)(3.39±1.12)g/L,分别高于对照A组与对照B组,差异有统计学意义(均P<0.05),但血浆凝血酶原时间(PT)(8.74±0.98)s,低于对照A组与对照B组,差异有统计学意义(均P<0.05)。结论:阻塞性睡眠呼吸暂停综合征是导致患者发生血栓的重要因素,对其进行早期诊断,对防范血栓发生具有重要意义。

Objective:To analyze the related factors of thrombosis in patients with cerebral infarction(CI)complicated with obstructive sleep apnea syndrome(OSAS).Methods:A total of 37 patients with cerebral infarction combined with obstructive sleep apnea syndrome who were admitted to Sanming First Hospital Affiliated to Fujian Medical University from November 2018 to November 2019 were selected as the research objects of the observation group.A total of 37 patients with obstructive sleep apnea syndrome and excluding cerebral infarction were selected as control group A,and 37 patients with cerebral infarction and excluding obstructive sleep apnea syndrome were selected as control group B.The body mass index,endothelin(ET)index,polysomnography(PSG)index and hemorheology index of the three groups were detected and analyzed.Results:There was no significant difference in body mass index between control group A,control group B and observation group(Ps>0.05).The endothelin index in the observation group was(132.67±38.58)pg/mL,which was much higher than that in control group A(77.39±43.51)pg/mL and control group B(76.24±42.87)pg/mL(Ps<0.05).The apnea hypopnea index(AHI)(62.34±13.28)and the longest apnea time(LAT)(87.39±18.34)seconds in the observation group were higher than those in control group A and control group B(Ps<0.05),but the lowest pulse oxygen saturation(LSpO2)(53.36±1.29)%was lower than those in control group A and control group B(Ps<0.05).The whole blood viscosity(WBV)(2.26±0.39)mPa·S and fibrinogen(FIB)(3.39±1.12)g/L in the observation group were higher than those in control group A and control group B(Ps<0.05),but the plasma prothrombin time(PT)(8.74±0.98)seconds was lower than those in control group A and control group B(Ps<0.05).Conclusion:Obstructive sleep apnea syndrome is an important factor leading to thrombosis.Early diagnosis is of great significance to prevent thrombosis.