五味祛脂颗粒辅助降血脂动物实验研究

Animal experimental study on Wuwei Quzhi Granules as an adjuvant therapy in reducing blood lipid

通过辅助降血脂动物试验研究,研究五味祛脂颗粒对高血脂症大鼠的降血脂作用。采取喂食高脂饲料的方法建立大鼠高血脂症模型,取高血脂模型大鼠40只,随机分为五味祛脂颗粒低、中、高剂量组以及模型对照组、非诺贝特阳性对照组。各组分别给予相应的受试物,每日1次,连续给样30 d,眼内眦取血,观察大鼠体重及血清TC、TG、LDL-C、HDL-C的含量。结果与模型对照组比较,五味祛脂颗粒各剂量组TC、TG、LDL-C含量随剂量增加而降低,中剂量组、高剂量组有显著性(或极显著性)差异(P<0.05或P<0.01),低剂量组也能够显著降低TG含量(P<0.05);五味祛脂颗粒各剂量组的HDL-C与模型组比较,差异有统计学意义(P<0.05或P<0.01)。在本试验条件下,五味祛脂颗粒具有辅助降血脂功能。

To study the hypolipidemic effect of Wuwei Quzhi Granules on hyperlipemia rats through auxiliary hypolipidemic animal experimental study,hyperlipidemia model rats was established by feeding high fat diet.40 hyperlipidemia model rats were randomly divided into model control group,fenofibrate group and the Wuwei Quzhi Granules low,medium and high dose group.The corresponding test substance were given once a day for 30 days.Blood was taken from the inner canthus of eyes,and TC,TG,LDL-C,HDL-C in rats were observed.The result shows that compared with the model control group,TC,TG,LDL-C in the Wuwei Quzhi Granules low,medium and high dose group increased with the increase of the dose,the difference between the medium and high dose groups was significant(P<0.05 or P<0.01),TG in the Wuwei Quzhi Granules low dose group increased with a significant difference(P<0.05).HDL-C in the Wuwei Quzhi Granules low,medium and high dose group had statistically significant difference(P<0.05 or P<0.01).Wuwei Quzhi Granules has the functions of the adjuvant therapy in reducing blood lipid.