2003—2021年国际冠状病毒的遗传学研究的发展态势及热点分析

The development trend and hotspots analysis of international genetics research of the coronavirus from 2003 to 2021

目的从发文时间、期刊、基金资助和引文角度对近20年冠状病毒遗传学研究的整体布局分析,识别该领域的核心研究机构及其合作网络,挖掘当前的研究热点。方法在PubMed和Web of Science数据库分别检索2003—2021年冠状病毒遗传学研究文献及其引文数据,利用Excel软件对文献的分布年代、机构分布和基金资助进行分析,再选择Citespace软件进行机构合作网络和文献同被引聚类分析。结果冠状病毒遗传学研究的文献在2020年有爆发式增长。载文量排名前10的期刊累计收录了23.4%的相关文献。在该领域发表文献最多的机构是中国科学院,前10所高产机构中,中国机构共有7所。在合作网络中,中国科学院、香港大学和圣保罗大学具有较高的中介中心度。基金资助论文的总被引次数和篇均被引次数均高于无基金资助论文。同被引聚类分析显示近20年共出现了7个研究热点,近5年仍活跃的为"中东呼吸综合征冠状病毒的基因序列和功能受体研究"、"新型冠状病毒的基因溯源与药物研发"和"美国突发性猪流行性腹泻病毒的基因分型、溯源和经济影响"。结论未来几年甚至更长久时期内,冠状病毒遗传学研究将处于一个持续高位阶段;发表相关领域高影响因子(IF>5.00)期刊论文有一定难度;中国科研机构在该领域研究非常活跃,尤其以中国科学院和香港大学最具影响力,他们与其他机构合作关系也最为紧密;关于冠状病毒的基因溯源、基因序列和功能受体以及药物研发极有可能是该领域研究前沿,我国政府应在该领域提前布局,加大相关科研基金立项数量和资金支持力度。

Objective To analyze the overall layout of coronavirus genetics research in the past 20 years from the perspective of publication time,journals,keywords,citations and funds,identify core research institutions and their cooperation networks in this field,and explore current research hotspots.Methods PubMed and Web of Science databases were searched separately for the research literature and citations data about coronavirus genetics from 2003 to 2021,and Excel was used to analyze the distribution of the literature and institutions,and then the Citespace software was selected for institutional cooperation network and reference co-citation cluster analysis.Results The literature about coronavirus genetics had increased significantly in 2020.The top 10 journals have collected 23.4%of relevant literature.Chinese Academy of Sciences has published the most documents in this field,in the top 10 high-yielding institutions,7 are from China.In the cooperation network,the Chinese Academy of Sciences,University of Hong Kong and University of Sao Paulo have high betweenness centrality.The total litation times and average citation times of funded papers were higher than those of non-funded papers.There have been 7 research hotspots in the past 20 years.The research on"the gene sequence and functional receptors of the Middle East respiratory syndrome coronavirus","the gene traceability and drug development of the SARS-Cov-2"as well as"genotyping,origin and economic impact of paroxysmal porcine epidemic diarrhea virus in the United States"are still active in the past five years.Conclusions Coronavirus genetics research will be at a sustained high level in the next few years or even longer.It is difficult to publish papers in journals with high impact factors(IF>5.00)in related fields.Chinese research institutions are active in this field.The Chinese Academy of Sciences and the University of Hong Kong are the most influential,and they have the closest cooperation with other institutions.The genetic tracing,gene sequence and functional receptor of coronavirus and drug development are likely to be the forefront of the research in this field.our govermment should advance the layout in this field and increase the number of research funds and financial support.