摘要
高危型人乳头瘤病毒(high-risk human papillomavirus,HR-HPV)持续感染是宫颈癌发生的明确病因,但并非所有HR-HPV感染都会导致宫颈癌,说明多种因素参与调节HR-HPV的致病性。Toll样受体(Toll-like receptors,TLRs)是一类模式识别受体,能特异性识别病原体相关分子模式(pathogen-associated molecular patterns,PAMPs)激发宿主抗病毒的固有和适应性免疫。相关研究表明HR-HPV通过调节TLRs的表达和信号通路改变局部免疫微环境,导致病毒持续感染以及宫颈癌发生。本综述将总结并讨论TLRs在HPV感染致宫颈癌中的免疫作用和可能的致病机制以及TLRs激动剂在HPV疫苗中的应用。
Persistent infection with high-risk human papillomavirus(HR-HPV)is a well-defined etiology of cervical cancer,but not all HR-HPV infections lead to cervical cancer,indicating that many factors are involved in the regulation of HR-HPV pathogenicity.Toll-like receptors(TLRs)are a class of pattern recognition receptors that specifically recognize pathogen-associated molecular patterns(PAMPs)to provoke host innate and adaptive immunity against viruses.Relevant studies have shown that HR-HPV alters the local immune microenvironment by regulating the expression and signaling pathways of TLRs,leading to persistent infection with HR-HPV as well as cervical cancer.This review summarized and discussed the immune function and possible pathogenesis of TLRs in HPV infection-caused cervical cancer and the application of TLRs agonists in HPV vaccines.
作者
张春林
龚权
梅冰
Zhang Chunlin;Gong Quan;Mei Bing(Department of Laboratory Medicine,Jingzhou Hospital,Yangtze University,Jingzhou 434020,China;Department of Immunology,Health Sciente Center,Yangtze University,Jingzhou 434023,China)
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2022年第1期73-77,共5页
Chinese Journal of Microbiology and Immunology
基金
2019年湖北省中央引导地方科技发展专项(2019ZYYD066)。