摘要
骨关节炎是中老年常见的慢性关节病,在绝经后妇女中发病率最高,提示该疾病应与绝经后雌激素水平的变化密切相关.雌激素及其受体在代谢机制中发挥多种作用,通过多种途径涉及关节软骨和软骨下骨的细胞增殖和凋亡,这成为绝经后女性骨关节炎高发的有力论据.目前,虽然关于雌激素及其受体代谢与骨关节炎相关性的研究并不缺乏,但最新的统一讨论仍然很少.因此,本文从雌激素及其受体影响经典Notch信号通路和胰岛素样生长因子、白细胞介素1 β、基质金属蛋白酶等软细胞代谢调节关节的共同机制,综述了雌激素及其受体与骨关节炎的关系.为今后进一步可能的研究方向提供参考.
Osteoarthritis,a common chronic joint disease in the middle-aged and the elderly with the highest incidence in the postmenopausal women,has been suggested that this disease should be closely related to the changes of postmenopausal estrogen levels.Estrogen and its receptors play many roles on metabolic mechanisms,involving cell proliferation and apoptosis of articular cartilage and subchondral bone by multiple ways,which has become a strong argument for the high incidence of osteoarthritis in postmenopausal women.At present,although there is no lack of studies on the correlation of estrogen and its receptor metabolism with osteoarthritis,the latest unified discussion on this topic remains rare.Therefore,this paper reviews the relationship of estrogen and its receptors with osteoarthritis by the common mechanism,such as estrogen and its receptors influencing the classic Notch signal channel and insulin-like growth factor,interleukin 1 beta,matrix metalloproteinases and other soft cell metabolism regulation of joint mechanism,to provide a reference for the future possible research direction further.
作者
陈威
苏耀辉
周明旺
魏长浩
CHEN Wei;SU Yao-hui;ZHOU Ming-wang;WEI Chang-hao(Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050,China;Gansu College of Traditional Chinese Medicine,Lanzhou 730000,China)
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2022年第3期235-239,共5页
Orthopedic Journal of China
基金
中医药传承创新平台建设项目(编号:18JR2FA009)。
关键词
雌激素
雌激素受体
骨关节炎
绝经
estrogen
estrogen receptor
osteoarthritis
menopause