中药活性成分调节PI3K/Akt信号通路在急性肺损伤治疗中的研究进展

Roles of Active Ingredients in Chinese Medicinals in Treatment of Acute Lung Injury by Regulating PI3K/Akt Signaling Pathway:A Review

急性肺损伤是一种常见的呼吸系统危重疾病,可进一步发展为急性呼吸窘迫综合征(ARDS),其病死率高,但目前没有明确有效的药物。磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/Akt)信号通路通过无数下游效应分子的磷酸化参与细胞增殖、代谢、存活和运动,在急性肺损伤的发生发展中发挥着重要作用,通过调节线粒体功能、细胞自噬、细胞凋亡、氧化应激和炎症反应等干预急性肺损伤。中药活性成分通过靶向PI3K/Akt信号通路对急性肺损伤具有一定的保护作用。目前中药活性成分调节PI3K/Akt信号通路治疗急性肺损伤的国内外相关基础研究日益增长,具有较好的临床研究价值。文章首次对近年来国内外PI3K/Akt信号通路与急性肺损伤之间的相关性研究进行综述,总结中药活性成分通过PI3K/Akt信号通路对急性肺损伤的保护作用,并创新性地将PI3K/Akt通路在急性肺损伤中的争议性趋势进行归纳梳理,为进一步指导中药治疗急性肺损伤的临床应用提供创新的思路和治疗策略。

Acute lung injury is a common critical respiratory disease,which can further develop into acute respiratory distress syndrome(ARDS)with a high fatality rate,but there is no effective drug at present.Phosphatidylinositol 3-kinase/protein kinase B(PI3K/Akt)signaling pathway is involved in cell proliferation,metabolism,survival,and motility through phosphorylation of numerous downstream effector molecules. It plays an important role in the development of acute lung injury by regulating mitochondrial function,apoptosis,autophagy,oxidative stress,and inflammatory response. The active ingredients in Chinese medicinals alleviate acute lung injury by targeting the PI3K/Akt signaling pathway. There has been an explosion of research on the treatment of acute lung injury by active ingredients in Chinese medicinals via PI3K/Akt signaling pathway,which is of great clinical research value. The article presented the first summary of studies exploring the correlation between PI3K/Akt signaling pathway and acute lung injury in recent years and summed up the protective effect of the active ingredients in Chinese medicinals against acute lung injury via PI3K/Akt signaling pathway,providing innovative mindsets and strategies for clinical application of active ingredients in Chinese medicinals in the treatment of acute lung injury.