辅助生殖技术受孕与自然受孕孕妇心理健康状况比较

Comparison of mental health status of pregnant women with assisted reproductive technology and natural pregnancy

目的探讨辅助生殖技术(ART)是否会影响孕妇孕期心理健康状况。方法采用便利抽样方法选取2019年7月至2020年7月在大连市妇女儿童医疗中心行产前检查的孕妇500例, 其中辅助生殖技术受孕孕妇(观察组)193例, 自然受孕孕妇(对照组)307例, 采用3D心身整体诊疗系统(PEM-D)结合90项症状自评量表(SCL-90)、广泛性焦虑量表(GAD-7)、抑郁症筛查量表(PHQ-9)、匹兹堡睡眠质量指数(PSQI)对2组孕妇的心理健康状况进行评估及比较。结果观察组SCL-90总分(154.34 ± 14.42)分, 明显高于对照组的(142.42 ± 14.39)分, 差异有统计学意义(t=5.35, P<0.05), 其中焦虑、抑郁、偏执评分观察组分别为(2.17 ± 0.47)、(2.15 ± 0.68)、(1.78 ± 0.45)分, 均明显高于对照组的(1.95 ± 0.52)、(1.77 ± 0.55)、(1.58 ± 0.39)分, 差异有统计学意义(t=2.86、3.88、3.20, 均P<0.05)。观察组GAD-7、PHQ-9评分分别为(6.72 ± 2.44)、(5.43 ± 2.54)分, 高于对照组的(5.76 ± 2.47)、(3.74 ± 1.66)分, 差异有统计学意义(t=2.52、3.57, 均P<0.05)。而观察组与对照组PSQI得分差异无统计学意义(P>0.05)。结论辅助生殖技术影响孕妇孕期的心理健康状况, 尤其是增加了抑郁情绪及焦虑情绪, 应该对这类孕妇提供相应心理支持与帮助, 以减轻其抑郁和焦虑情绪。

Objective To explore whether assisted reproductive technology(ART)can affect the mental health of pregnant women during pregnancy.Methods Convenient sampling method was used to select 500 pregnant women who underwent prenatal examination in Dalian Women and Children′s Medical Group from July 2019 to July 2020,including 193 cases of ART pregnant women(observation group)and 307 cases of natural pregnant women(control group).PEM-D psychosomatic holistic diagnosis and treatment system combined with Symptom Checklist-90(SCL-90),7-item Generalized Anxiety Disorder Scale(GAD-7),9-item Patient Health Questionnaire(PHQ-9)and Pittsburgh Sleep Quality Index(PSQI)were used to evaluate and compare the mental health status between the two groups.Results The total score of SCL-90 in the observation group was(154.34±14.42),which was significantly higher than that in the control group(142.42±14.39),the difference was statistically significant(t=5.35,P<0.05).The scores of anxiety,depression and paranoia in the observation group were(2.17±0.47),(2.15±0.68),(1.78±0.45),which were significantly higher than those in the control group(1.95±0.52),(1.77±0.55),(1.58±0.39),the differences were statistically significant(t=2.86,3.88,3.20,all P<0.015).The scores of GAD-7 and PHQ-9 in the observation group were(6.72±2.44),(5.43±2.54),which were significantly higher than those in the control group(5.76±2.47),(3.74±1.66),the differences were statistically significant(t=2.52,3.57,both P<0.05).There was no significant difference in PSQI scores between the two groups(P>0.05).Conclusions ART affects the mental health of pregnant women,especially increases the level of depression and anxiety.We should provide corresponding psychological support and help for these pregnant women to reduce their depression and anxiety level.