孕妇血清维生素A、E浓度与胎膜早破的相关性

Correlation between serum vitamin A,E concentration and premature rupture of membranes in pregnant women

目的:探讨孕妇妊娠期血清维生素A、E浓度及其与胎膜早破的相关性,以进行针对性的保健指导。方法:采用高效液相色谱法(HPLC)为195例孕妇检测血清维生素A、E浓度,分析不同年龄组孕妇血清维生素A、E的水平,及血清维生素A、E浓度与胎膜早破的关系。结果:195例孕妇中,有52例发生胎膜早破(占26.7%)。胎膜早破组维生素A缺乏及维生素E过量情况,高于非胎膜早破组(对照组),差异有统计学意义(P<0.05);不同年龄组孕妇维生素A均有不同程度的缺乏,总体缺乏率达46.7%,无过量现象;维生素E过量率达到44.44%,无一例缺乏。结论:孕期存在较为普遍的维生素A缺乏和维生素E过量现象,孕妇孕期血清维生素A、E浓度异常与胎膜早破的发生有相关性。孕期血清维生素A、E浓度检测有利于改善孕妇维生素A、E异常,预防胎膜早破的发生。

Objective:To study the concentration of serum vitamin A and E in pregnant women and their correlation with premature rupture of membranes,so as to provide targeted health care guidance.Methods:the serum vitamin A and E concentrations of 195 pregnant women were detected by high performance liquid chromatography(HPLC).The serum vitamin A and E levels of pregnant women in different age groups and the relationship between serum vitamin A and E concentrations and premature rupture of membranes were analyzed.Results:among 195 pregnant women,52 cases had premature rupture of membranes,accounting for 26.7%.Vitamin A deficiency and vitamin E excess in premature rupture of membranes group were higher than those in non premature rupture of membranes group(control group),the difference was statistically significant(P<0.05);Pregnant women in different age groups were deficient in vitamin A to varying degrees,and the overall deficiency rate was 46.7%;The excess rate of vitamin E reached 44.44%,and there was no lack of vitamin E.Conclusion:there are common phenomena of vitamin A deficiency and vitamin E excess during pregnancy.The abnormal concentration of serum vitamin A and E during pregnancy is related to the occurrence of premature rupture of membranes.The detection of serum vitamin A and E concentration during pregnancy is helpful to improve the abnormalities of vitamin A and E in pregnant women and prevent premature rupture of membranes.