持续性血液净化在急性肾功能衰竭治疗中的临床应用研究

Study on the clinical application of continuous blood purification in the treatment of acute renal failure

目的探讨持续性血液净化在急性肾功能衰竭治疗中的临床应用效果。方法30例急性肾功能衰竭患者,依据随机数字表法分为对照组与试验组,各15例。试验组患者接受持续性血液净化治疗,对照组患者接受间歇性血液净化治疗。比较两组治疗前和治疗2个月后的尿酸(UA)、血肌酐(Scr)、尿素氮(BUN)、白细胞介素6(IL-6)、C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)水平及治疗效果。结果治疗2个月后,两组UA、Scr、BUN、IL-6、CRP、TNF-α水平均低于本组治疗前,且试验组UA(396.54±22.74)μmol/L、Scr(115.06±12.13)μmol/L、BUN(6.81±1.02)mmol/L、IL-6(0.41±0.12)ng/L、CRP(7.93±1.32)mg/L、TNF-α(1.36±0.24)ng/ml均低于对照组的(425.14±24.06)μmol/L、(136.91±13.52)μmol/L、(7.95±1.16)mmol/L、(0.86±0.15)ng/L、(9.18±1.54)mg/L、(1.84±0.32)ng/ml,差异均有统计学意义(P<0.05)。试验组治疗总有效率93.33%高于对照组的60.00%,差异有统计学意义(P<0.05)。结论持续性血液净化在急性肾功能衰竭治疗中的临床应用能够获得良好的效果,不仅能够降低UA、Scr、BUN、IL-6、CRP、TNF-α水平,同时还能够提升临床治疗效果。

Objective To discuss the clinical effect of continuous blood purification in the treatment of acute renal failure.Methods A total of 30 patients with acute renal failure were randomly divided into control group and experimental group,with 15 cases in each group.Patients in the experimental group received continuous blood purification treatment,and patients in the control group received intermittent blood purification treatment.Both groups were compared in terms of uric acid(UA),serum creatinine(Scr),blood urea nitrogen(BUN),interleukin-6(IL-6),C-reactive protein(CRP)and tumor necrosis factor-α(TNF-α)before treatment and after 2 months of treatment,and therapeutic effect.Results After 2 months of treatment,the levels of UA,Scr,BUN,IL-6,CRP and TNF-α in the two groups were lower than those before treatment in this group;the UA(396.54±22.74)μmol/L,Scr(115.06±12.13)μmol/L,BUN(6.81±1.02)mmol/L,IL-6(0.41±0.12)ng/L,CRP(7.93±1.32)mg/L,TNF-α(1.36±0.24)ng/ml in the experimental group were lower than(425.14±24.06)μmol/L,(136.91±13.52)μmol/L,(7.95±1.16)mmol/L,(0.86±0.15)ng/L,(9.18±1.54)mg/L,(1.84±0.32)ng/ml in the control group;all the differences were statistically significant(P<0.05).The total effective rate of treatment 93.33% in the experimental group was higher than 60.00% in the control group,and the difference was statistically significant(P<0.05).Conclusion The clinical application of continuous blood purification can achieve good results in the treatment of acute renal failure.It can not only reduce the levels of UA,Scr,BUN,IL-6,CRP,and TNF-α,but also improve the clinical effect.