丁苯酞治疗急性脑梗死后轻度血管性认知功能障碍的疗效观察

Efficacy of butylphthalide in the treatment of mild vascular cognitive dysfunction after acute cerebral infarction

目的评价丁苯酞治疗急性脑梗死后轻度血管性认知功能障碍的临床疗效。方法92例急性脑梗死后轻度血管性认知功能障碍患者,按照入院先后顺序分为对照组和观察组,各46例。对照组采用尼莫地平治疗,观察组采用丁苯酞治疗。比较两组治疗效果、安全性及治疗前后简易精神状态检查量表(MMSE)、美国国立卫生研究院卒中量表(NIHSS)及日常生活能力量表(ADL)评分。结果观察组治疗总有效率91.30%高于对照组的65.22%,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。治疗前,两组MMSE、NIHSS及ADL评分比较,差异无统计学意义(P>0.05);治疗后,两组MMSE、NIHSS及ADL评分均优于治疗前,且观察组MMSE评分(26.20±2.60)分、NIHSS评分(9.05±1.30)分及ADL评分(78.50±4.05)分均优于对照组的(20.30±1.55)、(11.20±1.50)、(69.50±3.50)分,差异有统计学意义(P<0.05)。结论对急性脑梗死后轻度血管性认知功能障碍患者应用丁苯酞治疗,其治疗效果显著,具有较高安全性,可有效改善患者认知功能障碍,提高患者生活质量。

Objective To evaluate the clinical efficacy of butylphthalide in the treatment of mild vascular cognitive dysfunction after acute cerebral infarction.Methods A total of 92 patients with mild vascular cognitive dysfunction after acute cerebral infarction were divided into control group and observation group according to the order of admission,with 46 cases in each group.The control group was treated with nimodipine,and the observation group was treated with butylphthalide.Both groups were compared in terms of therapeutic effect,safety,mini mental state examination(MMSE)score,National Institutes of Health stroke scale(NIHSS)score and activities of daily living(ADL)score before and after treatment.Results The total effective rate 91.30% of the observation group was higher than 65.22% of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Before treatment,there was no statistically significant difference in MMSE,NIHSS and ADL scores between the two groups(P>0.05).After treatment,the MMSE,NIHSS and ADL scores of the two groups were better than those of this group before treatment,and the MMSE score(26.20±2.60)points,NIHSS score(9.05±1.30)points and ADL score(78.50±4.05)points of the observation group were better than(20.30±1.55),(11.20±1.50),and(69.50±3.50)points of the control group.All the differences were statistically significant(P<0.05).Conclusion Butylphthalide has significant therapeutic effect and high safety on patients with mild vascular cognitive dysfunction after acute cerebral infarction,and can effectively improve the cognitive dysfunction and the quality of life of patients.