克拉霉素联合替硝唑治疗小儿胃炎的临床疗效分析

Clinical efficacy of clarithromycin combined with tinidazole in the treatment of gastritis in children

目的探讨克拉霉素结合替硝唑在小儿胃炎治疗中的临床效果。方法80例胃炎患儿,采用系统抽样法分为对照组和观察组,每组40例。对照组患儿采用阿莫西林联合甲硝唑治疗,观察组患儿采用克拉霉素联合替硝唑治疗。比较两组治疗效果、不良反应发生情况和临床症状改善时间。结果观察组治疗总有效率为92.50%,高于对照组的70.00%,差异具有统计学意义(P<0.05)。观察组口苦口干、胃脘胀满、嗳气反酸、胃脘疼痛改善时间均短于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为5.00%(2/40),低于对照组的20.00%(8/40),差异具有统计学意义(P<0.05)。结论克拉霉素联合替硝唑治疗小儿胃炎效果明显,不仅可以及早改善胃脘疼痛、口苦口干、嗳气反酸等临床症状,提高治疗效果,且不良反应少,值得临床进一步采纳与推广。

Objective To discuss the clinical effect of clarithromycin combined with tinidazole in the treatment of gastritis in children.Methods A total of 80 children with gastritis were divided into control group and observation group by systematic sampling method,with 40 cases in each group.Children in the control group were treated with amoxicillin and metronidazole,and children in the observation group were treated with clarithromycin and tinidazole.The therapeutic effect,occurrence of adverse reactions and clinical symptom improvement time were compared between the two groups.Results The total effective rate of treatment in the observation group was 92.50%,which was higher than 70.00% in the control group,and the difference was statistically significant(P<0.05).The improvement time of bitterness and dry mouth,epigastric fullness,belching and acid reflux,and epigastric pain in the observation group were shorter than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 5.00%(2/40),which was lower than 20.00%(8/40)in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of clarithromycin and tinidazole has obvious effect in the treatment of children with gastritis.It can not only improve the clinical symptoms of epigastric pain,bitter mouth and dry mouth,belching and acid reflux as soon as possible,but also improve the therapeutic effect with less adverse reactions,which is worthy of further clinical adoption and promotion.