对比泮托拉唑、奥美拉唑治疗胃溃疡的疗效

Efficacy of pantoprazole and omeprazole in the treatment of gastric ulcer

目的探究胃溃疡治疗中采用泮托拉唑与奥美拉唑的临床价值。方法82例胃溃疡患者,采用随机数字表法分为对照组和观察组,每组41例。对照组采用奥美拉唑治疗,观察组采用泮托拉唑治疗。比较两组临床效果、生活质量、不良反应发生情况及嗳气、腹胀、上腹部疼痛消失时间。结果观察组总有效率为92.68%,高于对照组的68.29%,差异具有统计学意义(P<0.05)。观察组嗳气、腹胀、上腹部疼痛消失时间分别为(2.59±0.33)、(2.38±0.13)、(2.99±0.19)d,明显短于对照组的(4.76±0.65)、(4.76±0.28)、(5.56±0.29)d,差异具有统计学意义(P<0.05)。治疗后,两组社会功能、认知功能、情绪状态、角色功能、躯体功能评分均高于本组治疗前,且观察组高于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为4.88%(2/41),低于对照组的31.71%(13/41),差异具有统计学意义(P<0.05)。结论与奥美拉唑相比,胃溃疡采用泮托拉唑治疗的效果更明显,可明显缩短嗳气、腹胀、上腹部疼痛消失时间,提高患者生活质量,减少不良反应发生,值得临床推广应用。

Objective To investigate the clinical value of pantoprazole and omeprazole in the treatment of gastric ulcer.Methods A total of 82 patients with gastric ulcer were divided into control group and observation group by random numerical table,with 41 cases in each group.The control group was treated with omeprazole,and the observation group was treated with pantoprazole.The clinical effect,quality of life,occurrence of adverse reactions,and disappearance time of belching,abdominal distension and epigastric pain were compared between the two groups.Results The total effective rate of the observation group was 92.68%,which was higher than 68.29% of the control group,and the difference was statistically significant(P<0.05).The disappearance times of belching,abdominal distension and epigastric pain in the observation group were(2.59±0.33),(2.38±0.13)and(2.99±0.19)d,which were significantly shorter than(4.76±0.65),(4.76±0.28)and(5.56±0.29)d in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of social function,cognitive function,emotional state,role function and somatic function in both groups were higher than before treatment in this group,and the observation group was higher than the control group.All the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 4.88%(2/41),which was lower than 31.71%(13/41)in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with omeprazole,pantoprazole is more effective in treating gastric ulcer,which can shorten the time of belching,abdominal distension and epigastric pain,improve the quality of life and reduce the occurrence of adverse reactions.It is worthy of clinical promotion and application.