不良生活习惯对精子DNA碎片率的影响

The effect of unhealthy lifestyle on sperm DNA fragmentation rate

目的:调查不良生活习惯对男性精子DNA碎片率增高的影响。方法:本研究以2019年11月-2020年2月在广州中医药大学第一附属医院泌尿外科门诊就诊的、具有精子DNA碎片指数(DNA Fragmentation Index,DFI)检测结果的男性不育症患者为研究对象,总共214例:精子DFI正常组为99例,精子DFI增高组为115例。问卷调查了解其生活习惯,并做单因素及多因素研究分析。结果:对不良生活习惯行单因素分析,吸烟、熬夜、久坐的P值分别为0.018、0.027、0.036,均小于0.05,差异具有统计学意义;进一步行二元Logistic回归分析,结果显示吸烟所对应的P值=0.038<0.05。结论:吸烟、熬夜、久坐是精子DNA碎片率增高的可疑影响因素,吸烟是精子DNA碎片率增高的独立影响因素。

Objective:To investigate the effect of unhealthy lifestyle on the increased rate of sperm DNA fragmentation in males.Methods:In this study,214 male infertility patients with sperm DFI test results who visited the Urology Department of the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine from November 2019 to February 2020 were selected as the research subjects,and were divided into groups.There were 99 cases in the normal sperm DFI group and 115 cases in the increased sperm DFI group.Questionnaire survey was made to understand their living habits,and single factor and multiple factors research analysis was made.Results:Single factor analysis of unhealthy living habits showed that the P values of smoking,staying up late and sitting for long were 0.018,0.027 and 0.036,respectively,which were all less than 0.05,with statistical significances.Further binary logistic regression analysis showed that the P value of smoking was 0.038<0.05.Conclusion:Smoking,staying up late,and sitting for a long time are suspected factors affecting the increase of sperm DNA fragmentation rate,and smoking is an independent factor affecting the increase of sperm DNA fragmentation rate.