NT-proBNP、MYO、cTnI对急性心肌梗死PCI后预后评估中的价值

The value of NT-proBNP,MYO,cTnI in prognostic evaluation after AMI and PCI

目的探讨血清氨基末端脑钠肽前体(NT-proBNP)、肌红蛋白(MYO)及肌钙蛋白I(cTnI)在急性心肌梗死(Acute myocardial infarction,AMI)患者病情程度判断、经皮冠状动脉介入术(Percutaneous coronary intervention,PCI)后预后评估中的价值。方法选取2017年1月~2020年1月北京中西医结合医院确诊的100例AMI患者作为AMI组、60例不稳定型心绞痛患者作为对照组;检测对比两组入院后的血清NT-proBNP、MYO、cTnI水平,并根据冠状动脉病变支数进行分层对比;分析上述指标与Gensini评分的相关性。结果AMI组患者的血清NT-proBNP、MYO、cTnI水平均高于对照组,差异具有统计学意义(P<0.05);三支病变的AMI组患者的血清NT-proBNP、MYO、cTnI水平均高于双支病变、单支病变的患者,差异具有统计学意义(P<0.05);双支病变的AMI组患者的血清NT-proBNP、MYO、cTnI水平均高于单支病变的患者,差异均具有统计学意义(P<0.05);100例AMI患者的Gensini评分为(53.9±7.0)分,血清MYO、cTnI与Gensini评分呈显著的正相关关系(P<0.05)。结论血清NT-proBNP、MYO、cTnI水平与AMI患者冠状动脉病变支数增加有关系,PCI术前血清NT-proBNP、MYO水平增高会增大患者术后不良心血管事件(MACE)事件发生的概率。

Objective To explore the evaluation of serum N-terminal pro-brain natriuretic peptide(NT-proBNP),myoglobin(MYO)and troponin I(cTnI)in patients with acute myocardial infarction(AMI)and percutaneous coronary intervention(PCI)value in post-prognosis assessment.Methods Select 150 AMI patients diagnosed in our hospital as the AMI group,and 80 patients with stable angina pectoris as the mutation;test and compare the serum NT-proBNP,MYO,cTnI levels after entering the hospital,and perform stratified comparison according to the number of coronary artery lesions;Analyze the correlation between the above indicators and Gensini score.Results The serum NT-proBNP,MYO and cTnI levels of the AMI group were higher than those of the control group,and the difference was statistically significant(P<0.05);the serum NT-proBNP,MYO and cTnI levels of the AMI group with three-vessel disease were higher than those of the control group The difference between patients with double-vessel disease and single-vessel disease was statistically significant(P<0.05);the serum NT-proBNP,MYO,and cTnI levels of patients in the AMI group with double-vessel disease were higher than those with single-vessel disease,and the differences were all statistical significance(P<0.05);the Gensini score of 150 AMI patients was 53.9±7.0 points,and the serum MYO,cTnI and Gensini score were significantly positively correlated(P<0.05).Conclusion Serum NT-proBNP,MYO,cTnI levels are related to the increase in the number of coronary artery lesions in patients with AMI.The increased serum NT-proBNP and MYO levels before PCI will increase the probability of MACE events after surgery.