胰岛素泵短期强化疗法应用在妊娠糖尿病治疗中的效果

The Effect of Short-term Intensive Insulin Pump Therapy in the Treatment of Gestational Diabetes

目的探究胰岛素泵短期强化疗法应用在妊娠糖尿病治疗中的效果。方法选取2019年5月—2020年5月该院60例妊娠糖尿病患者作为研究对象,发放随机信封根据单双号分为观察组(胰岛素泵短期强化疗法)与对照组(常规胰岛素注射),各30例。比较两组患者血糖达标时间、胰岛素用量、治疗前后血糖指标改善情况,随访不良反应发生情况及患者妊娠结局。结果观察组患者血糖达标时间短于对照组,胰岛素用量少于对照组,差异有统计学意义(P<0.05);两组患者治疗前空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1c)差异无统计学意义(P>0.05),治疗后两组FPG、2 hPG、HbA1c水平均降低,观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较观察组低于对照组,差异有统计学意义(P<0.05);观察组不良妊娠结局发生率低于对照组,差异有统计学意义(P<0.05)。结论胰岛素泵短期强化疗法应用于妊娠糖尿病治疗,在改善患者血糖指标方面有突出效果,能够减少胰岛素用量,不良反应少,可改善妊娠结局,值得推广。

Objective To explore the effect of short-term intensive insulin pump therapy in the treatment of gestational diabetes.Methods From May 2019 to May 2020,60 patients with gestational diabetes in the hospital were selected as the research objects.Randomly distributed envelopes were divided into observation group(short-term intensive insulin pump therapy)and control group(regular insulin injection)according to the odd and even numbers,with 30 cases in each group.The time to reach the standard of blood glucose,insulin dosage and the improvement of blood glucose index before and after the treatment were compared between the two groups of patients,the occurrence of adverse reactions and the pregnancy outcome of the patients were followed up.Results The observation group had shorter blood glucose compliance time than the control group,and the insulin consumption was less than that of the control group,the difference was statistically significant(P<0.05).There was no statistically significant difference in fasting blood glucose(FPG),postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1c)between the two groups of patients before treatment(P>0.05).After treatment,the levels of FPG,2 hPG,and HbA1c in the two groups decreased.The observation group was lower than the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions between the two groups was lower in the observation group than in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse pregnancy outcomes in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The short-term intensive therapy of insulin pump used in the treatment of gestational diabetes has outstanding effects in improving the blood glucose index of patients.It can reduce the dosage of insulin,has fewer adverse reactions,and can improve pregnancy outcome.It is worthy of promotion.