含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方改善轻、中度痤疮症状的临床观察

Clinical efficacy of a topical formula containing glycolic acid,salicylic acid,lipohydroxy acid,and niacinamide in patients with mild to moderate acne

目的:评价含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方改善轻、中度痤疮临床症状的有效性和安全性。方法:招募66例轻、中度女性痤疮患者,按要求使用测试产品28 d后停用14 d,分别在使用前、使用7 d和28 d以及停用7 d和14 d后由皮肤科医生进行痤疮皮损计数、痤疮炎症后红斑和色素沉着计数、毛孔可见度和肤色均匀度评级,拍摄面部标准照片并进行图像分析,并由患者完成自我评价问卷。结果:共有42例患者完成全部试验。与使用前相比,测试产品在使用后7 d和28 d能显著减少非炎性和炎性皮损数量,改善毛孔可见度和肤色均匀度,并且在停用后14 d内仍能维持效果。此外,测试产品对于肤色、红斑程度/面积及血流灌注等图像分析指标也有显著的改善作用。患者对测试产品耐受良好,表现出了较高的满意度和持续使用的意愿。结论:含乙醇酸、水杨酸、辛酰水杨酸和烟酰胺的外用配方对于改善轻、中度痤疮临床症状具有较好的有效性和安全性,减少皮损同时能减轻痤疮炎症后红斑和色素沉着并改善肤质和肤色。

Objective:To evaluate the effectiveness and safety of a topical formula containing glycolic acid,salicylic acid,lipohydroxy acid,and niacinamide in patients with mild to moderate acne.Methods:Sixty-six subjects with mild to moderate acne were recruited and used test product for 28 d and then stopped for 14d.Dermatological evaluations were performed to count acne lesions,quantify post-inflammatory erythema and hyperpigmentation,and grade the extent of pore visibility and skin tone evenness.Standard facial photos were taken,and image analysis was conducted.The subjects also filled self-assessment questionnaires.Results:Forty-two subjects completed the whole study.Comparing to baseline,the test formula reduced non-inflammatory and inflammatory lesions,and improved pore visibility and skin tone evenness at 7 d and 28 d after use.The improvement sustained for 14 d after stopping the use of the product The test formula also produced improvement in skin tone,ery-thema intensity and area,and blood flow,according to the image analysis parameters.The product presented good skin tolerance and the subjects showed satisfaction and willingness for long-term use of it.Conclusion:The topical formula containing glycolic acid,salicylic acid,lipohydroxy acid,and niacinamide showed good effectiveness and safety in patients with mild to moderate acne.It not only reduced lesion count,but also improved post-inflammatory erythema and hyperpigmentation,as well as skin texture and color.