基于“邪伏膜原”理论探讨溃疡性结肠炎炎癌转化的机制及论治

Based on the theory of "Latent pathogens trapped in the membrane source" to explore the mechanism and treatment of ulcerative colitis cancer transformation

溃疡性结肠炎(ulcerative colitis,UC)是一种病因不明的慢性炎症性肠病(inflammatory bowel disease,IBD),其特征是持续性炎症,多起源于直肠,并以连续方式向近端延伸至结肠。炎症通常局限于黏膜层,造成肠道的浅溃疡,症状主要表现为黏液脓血便。目前,UC的发病率和流行率在世界范围内呈上升趋势。在1955年使用皮质类固醇之前,中到重度UC患者的死亡率超过50%[1]。

Ulcerative colitis(UC) is a chronic non-specific intestinal inflammation of unknown etiology.It is difficult to cure and often recurs.With the prolonged course of the disease and the expansion of the scope of the disease,the risk of cancer gradually increases.It is recognized by the World Health Organization and listed as one of the modern refractory diseases.The author combines the theory of ’latent pathogens trapped in the membrane source’ of traditional Chinese medicine with the inflammatory cancer transformation mechanism of UC.It is believed that the damp-heat terminus recurs in the intestines,damages the intestinal collaterals,and stagnates Qi and blood.Latent pathogens are stagnant in the membranous membrane,accumulate,and forms poison over time,and the development of a mass is the key to the pathogenesis of UC to inflammatory cancer.The theoretical basis is explained from the pathogenesis of Chinese medicine and modern medicine,and the system of UC differentiation and treatment is perfected for clinical treatment.It provides new ideas for the clinical treatment of the disease.