重视儿童急性肝衰竭的诊治

The diagnosis and treatment of pediatric acute liver failure should be taken seriously

儿童急性肝衰竭(PALF)临床上虽少见,但起病急,进展快,严重威胁着儿童的生命和健康。其病因多样,目前较多患儿最终仍未能明确病因。PALF的临床表现与成人有所不同,婴幼儿早期肝性脑病的判断有一定的难度。维持内环境的稳定及病因治疗对于PALF极为重要,应避免乱用药、滥用血制品,有指征的患儿可行血液净化治疗为自体肝功能恢复和肝移植赢得更多的时间。PALF的精准诊治需要受到更多的重视。

Although pediatric acute liver failure(PALF)is rare in clinical practice,it seriously threatens the life and health of children due to acute onset and rapid progression.PALF has various etiologies,and at present,it is still unable to identify the etiology in a relatively large proportion of children.The clinical manifestations of PALF are also different from those of adults,and it is difficult to judge early hepatic encephalopathy in infants and young children.It is very important to maintain the stability of internal environment,provide etiological treatment,and avoid drug abuse and the abuse of blood products.Blood purification can be performed for patients with related indications to win more time for autogenous liver function recovery and liver transplantation,and the precise diagnosis and treatment of PALF should be taken seriously in clinical practice.