银杏二萜内酯葡胺注射液治疗脑梗死的临床效果及对神经功能的影响

Effects of ginkgo diterpene lactone meglumine injection on nerve function in patients with cerebral infarction

目的观察脑梗死患者采用银杏二萜内酯葡胺注射液治疗的临床效果,并分析该治疗方法对患者神经功能的影响。方法选取2019年3月-2020年9月广东省怀集县人民医院收治的脑梗死患者70例,根据随机数字表法分为研究组和对照组,每组35例。2组均采取常规治疗,在此基础上研究组加以银杏二萜内酯葡胺注射液治疗,2周为1个疗程。比较2组患者治疗前后血液流变学指标全血黏度(低切、中切和高切)、神经功能缺损评分(NIHSS)、简易智力状态检查量表(MMSE)、日常生活能力评分(ADL)及临床治疗总有效率。结果治疗2周后,2组全血黏度低切、中切和高切数值均较治疗前降低(P <0.01),且研究组患者的全血黏度低切、中切和高切低于对照组(P均<0.01);2组NIHSS评分较治疗前降低,MMSE、ADL评分较治疗前升高(P均<0.01),且研究组的NIHSS评分低于对照组,MMSE、ADL评分高于对照组(P均<0.01);研究组临床治疗总有效率为88.57%,高于对照组的68.57%(χ^(2)=4.158,P=0.041)。结论脑梗死患者采用银杏二萜内酯葡胺注射液治疗效果显著,能有效改善患者脑部血液流变学指标,降低全血黏度,改善神经功能,以促进患者认知功能和日常生活能力的提升。

Objective To observe the clinical effect of ginkgo diterpene lactone meglumine injection in patients with cerebral infarction,and to analyze the effect of this treatment on nerve function.Methods 70 patients with cerebral infarction admitted to the Huaiji County People’s Hospital from March 2019 to September 2020 were divided into study group and control group according to the random number table method,with 35 cases in each group.Both groups were treated with conventional treatment.On this basis,the study group was treated with ginkgo diterpene lactone meglumine injection,2 weeks as a course of treatment.Compare the two groups of patients before and after treatment,blood rheology indexes,whole blood viscosity( low cut,medium cut and high cut),neurological impairment score( NIHSS),simple mental status check scale( MMSE),daily living ability score( ADL) and the total effective rate of clinical treatment.Results After 2 weeks of treatment,the low cut,medium cut and high cut whole blood viscosity values of the two groups were lower than before treatment( P < 0.01),and low cut,medium cut and high cut whole blood viscosity of the study group were lower than those of the control group( all P <0.01);The NIHSS scores of the two groups were lower than before treatment,and the MMSE and ADL scores were higher than before treatment( P < 0.01),and the NIHSS score of the study group was lower than that of the control group,and the MMSE,ADL scores were higher than that of the control group( all P < 0.01);The total effective rate of clinical treatment in the study group was 88.57%,which was higher than 68.57% in the control group( χ^(2)= 4.158,P = 0.041).Conclusion The treatment of cerebral infarction patients with ginkgo diterpene lactone meglumine injection has a significant effect,which can effectively improve the patients’ brain hemorheology indexes,reduce the whole blood viscosity,improve neurological function,and promote the improvement of patients’ cognitive function and daily living ability.