三伏贴治疗慢性阻塞性肺疾病稳定期患者的疗效及作用机制研究

Study on the efficacy and mechanism of sanfu patch in the treatment of stable chronic obstructive pulmonary disease patients

目的通过检测治疗前后患者血清白细胞介素-5(IL-5)、肿瘤坏死因子-α(TNF-α)的水平变化,探讨在慢性阻塞性肺疾病稳定期患者的治疗当中采用三伏贴治疗的效果。方法选取2019年6月至8月攀枝花学院附属医院收治的80例COPD稳定期患者为研究对象,按照随机数字表法分为治疗组和对照组,各40例。对照组患者维持常规治疗方案,治疗组患者在对照组的基础上加用三伏贴治疗。比较两组患者治疗前和治疗后3个月的身体各项指标变化。结果治疗组患者血清IL-5和TNF-α水平、CAT评分、SGRQ评分、6MWT及肺功能较治疗前均有明显改善(P<0.05);对照组患者治疗前后各指标比较,差异无统计学意义(P>0.05)。治疗后治疗组患者的各项临床症状明显改善,中医症候积分降低,肺功能提升,因此,治疗组中医症候积分低于对照组,肺功能指标优于对照组(P<0.05);治疗组患者治疗有效率高于对照组(P<0.05)。结论三伏贴通过降低COPD稳定期患者血清IL-5、TNF-α水平,改善CAT评分、SGRQ评分、6MWT及肺功能,效果较好。

Objective By detecting the changes of serum interleukin-5(IL-5)and tumor necrosis factor-α(TNF-α)before and after treatment,to explore the effect of Sanfu patch in the treatment of patients with chronic obstructive pulmonary disease at stable stage.Methods A total of 80 patients with stable COPD who were admitted to the Affiliated Hospital of Panzhihua University from June to August 2019 were selected as the research objects,and were divided into a treatment group and a control group according to the random number table method,with 40 cases in each.The patients in the control group maintained the conventional treatment plan,and the patients in the treatment group were additionally treated with Sanfu patch on the basis of the control group.The levels of serum IL-5,TNF-α,chronic obstructive pulmonary disease assessment test(CAT)score,St.George's Respiratory Questionnaire(SGRQ)score,6-minute walk test(6MWT)and pulmonary function were compared between the two groups before treatment and 3 months after treatment.Results Serum IL-5 and TNF in the treatment group-αLevel,cat score,SGRQ score,6MWT and pulmonary function were significantly improved compared with those before treatment(P<0.05);There was no significant difference in the indexes of the control group before and after treatment(P>0.05).After treatment,the clinical symptoms of the patients in the treatment group were significantly improved,the TCM syndrome score was reduced,and the pulmonary function was improved.Therefore,the TCM syndrome score in the treatment group was lower than that in the control group,the pulmonary function index was better than that in the control group(P<0.05);The effective rate of the treatment group was higher than that of the control group(P<0.05).Conclusion Sanfu patch can improve the CAT score,SGRQ,6MWT and pulmonary function in patients with stable COPD by reducing the levels of serum IL-5 and TNF-α.。