基于数据挖掘分析雷枭治疗慢性失眠用药规律

An Analysis of Medication Law of Lei Xiao in the Treatment of Chronic Insomnia Based on Data Mining

目的:基于中医传承计算平台分析雷枭教授治疗慢性失眠的用药规律。方法:收集2020年1—12月就诊于川北医学院附属医院中医科雷枭教授门诊,且病程>3个月的慢性失眠患者医案,构建雷枭教授治疗慢性失眠的门诊数据库。使用中医传承计算平台对处方药物的频次、四气、五味、归经、功效及关联规则、核心组合进行挖掘,同时对舌、脉及伴随症状进行频次分析。结果:共纳入245首处方,涉及药物110味,其中,平、温、甘、苦为高频性味,心经、脾经为高频归经,药物功效以补虚药和安神药为主。"何首乌藤、茯神""何首乌藤、炙甘草"为高频药物组合,共提取4个核心药物组合。出现频次最高的舌象、脉象分别为舌淡暗、苔薄白、脉弱;伴随症状中频次排列前3位的是神疲乏力、心烦、多梦。结论:雷枭教授治疗慢性失眠主要从心、脾、肝三脏论治,虚实兼顾,以补益心脾、养血安神为主,兼以疏肝解郁、清热化痰、平肝潜阳、益阴安神。

Objective:To analyze the medication law of Professor Lei Xiao in the treatment of chronic insomnia based on the Traditional Chinese Medicine Inheritance Computing Platform.Methods:The medical records of patients with chronic insomnia with a course of more than 3 months were collected from Professor Lei Xiao′s clinic in the Affiliated Hospital of North Sichuan Medical College from January to December 2020,and the outpatient database of Professor Lei Xiao′s treatment of chronic insomnia was constructed.Traditional Chinese Medicine Inheritance Computing Platform was used to mine the frequency,four natures,five flavors,meridian tropism,efficacy,association rules and core combination of formula drugs,and analyze the frequency of tongue,pulse and accompanying symptoms.Results:A total of 245 formulas were included,involving 110 kinds of drugs,of which mild,warm,sweet and bitter were high-frequency flavors,the heart meridian and the spleen meridian were high-frequency meridians,and the drug efficacy mainly came from tonifying medicinals and tranquilizing medicinals.Heshouwu(Radix Polygoni Multiflori)-Fushen(Sclerotium Poriae Pararadicis),Heshouwu(Radix Polygoni Multiflori)-Zhigancao(Radix Glycyrrhizae Praeparata) were the high-frequency drug combinations.Four core drug combinations were extracted.The tongue and pulse manifestations with the highest frequency were light and dark tongue,thin and white fur and weak pulse.The top three in the frequency of accompanying symptoms were mental fatigue,vexation and dreaminess.Conclusion:Professor Lei Xiao′s treatment of chronic insomnia mainly focuses on the treatment of the heart,spleen and liver,giving consideration to both deficiency and excess,mainly tonifying the heart and spleen,nourishing blood and calming the mind,as well as soothing the liver and resolving depression,clearing heat and resolving phlegm,pacifying the liver and subduing yang,replenishing yin and calming the mind.