抗生素降阶梯治疗管理方案在重症肺炎患者中的临床应用

Clinical application of antibiotic de-escalation treatment management plan in patients with severe pneumonia

目的 探究抗生素降阶梯治疗管理方案在重症肺炎患者中的临床应用情况。方法 选取2017年5月至2020年5月本院收治的80例重症肺炎患者作为研究对象,随机分为常规组和干预组,各40例。常规组患者予以常规抗生素治疗方案管理,干预组患者予以抗生素降阶梯治疗方案管理,比较两组治疗后C-反应蛋白、D-二聚体、降钙素原指标的数值变化、治疗情况、临床疗效及不良反应发生率。结果 治疗后,干预组C-反应蛋白、D-二聚体、降钙素原水平明显低于常规组(P<0.05);干预组治疗总有效率高于常规组(P<0.05);干预组ICU治疗时间、住院时间、抗生素使用时间均短于常规组(P<0.05);干预组不良反应发生率低于常规组(P<0.05)。结论 抗生素降阶梯治疗管理方案能明显改善重症肺炎患者的临床症状,相较于传统抗生素治疗方案临床疗效显著。

Objective To explore the clinical application of antibiotic de-escalation treatment management plan in patients with severe pneumonia.Methods 80 patients with severe pneumonia treated in our hospital from May 2017 to May 2020 were selected as the research subjects,and randomly divided into routine group and intervention group,with 40 cases in each group.Patients in the routine group were treated with conventional antibiotics program management,patients in the intervention group were given antibiotic de-escalation treatment program management.The numerical changes of C-reactive protein,D-dimer and procalcitonin indexes,treatment conditions,clinical efficacy and incidence of adverse reactions were compared between the two groups after treatment.Results The levels of C-reactive protein,D-dimer and procalcitonin in the intervention group were significantly lower than those in the routine group(P<0.05);the total effective rate of the intervention group was higher than that in the routine group(P<0.05);the ICU treatment time,hospital stay and antibiotic use time in the intervention group were shorter than those in the routine group(P<0.05);the incidence of adverse reactions in the intervention group was lower than that in the routine group(P<0.05).Conclusion The antibiotic de-escalation treatment management scheme can significantly improve the clinical symptoms of severe pneumonia patients,and the clinical efficacy is significant compared with the traditional antibiotic treatment scheme.