苦豆子生物碱对溃疡性结肠炎治疗机制的研究进展

The Research Progress on the Treatment Mechanism of Alkaloids of Sophora alopecuroides for Ulcerative Colitis

苦豆子(Sophora alopecuroides)为豆科槐属多年生草本植物,分布于我国西北地区荒漠、半荒漠草地,在陕西的分布主要在陕西北部毛乌素沙地边缘,其分布面积广,蕴藏量大。苦豆子主要化学成分有生物碱和黄酮等,具有明显的抗炎、抗心律失常、抗癌、镇痛和抗变态反应等作用。溃疡性结肠炎是一种表现为长期或间歇性的腹泻、血便、黏液便和里急后重等临床症状的慢性非特异性炎症疾病。西医药物治疗溃疡性结肠炎,长期使用往往会引起多种副作用。因此,本文对苦豆子的分布、苦豆子生物碱的药理作用和苦豆子对结肠炎的治疗机制进行综述,为苦豆子的药用植物资源开发和生态保护提供新的思路和研究方向。

Sophora alopecuroides is a perennial leguminousherb,distributed in desert and semi-desert grasslands in northwest China with a large area and reserve.The main chemical components of Sophora alopecuroides are alkaloid and flavone,with the function of anti-inflammation,anti-arrhythmic,anti-cancer,analgesic and anti allergy,etc..The clinical symptoms of ulcerative colitis are long-term or episodes of diarrhea,abdominal pain,bloody stool,mucus stool,and chronic nonspecific inflammatory disease.Chemical drugs treatment for ulcerative colitis has been used for a long time,with some other bad effects.Therefore,the main content of paper includes the distribution of sophora alopecuroides,the pharmacological effects of alkaloids of Sophora alopecuroides and the mechanism of treatment for ulcerative colitis,which can provide plant resources development and ecological protection with new thoughts and research direction.