2型糖尿病患者血糖、胰岛素水平与帕金森病发生风险的关系

The Relationship Between Blood Glucose, Insulin Levels and the Risk of Parkinson’s Disease in Patients with Type 2 Diabetes

目的探讨2型糖尿病患者血糖、胰岛素水平与帕金森病发生风险的关系。方法选取2019年3月—2021年3月该院确诊的342例2型糖尿病,其中合并帕金森病的80例患者作为观察组,不合并帕金森病的262例患者作为对照组。比较两组患者的血糖和胰岛素水平并分析血糖和胰岛素水平与帕金森病的相关性。结果两组患者空腹血糖和胰岛素水平比较,观察组患者的空腹血糖较对照组高,但胰岛素水平低于对照组,差异有统计学意义(P<0.05)。帕金森病的发病率随血糖水平升高而升高,随胰岛素水平降低而降低。采用线性相关分析,2型糖尿病患者血糖水平与帕金森病相关性分析,二者存在高度正相关(r=0.786);2型糖尿病患者胰岛素水平与帕金森病相关性分析,二者存在显著负相关(r=-0.678)。结论2型糖尿病可导致空腹血糖和胰岛素水平的异常,增加帕金森病的发病风险,因此调控2型糖尿病的糖代谢异常和胰岛素分泌可减轻患者的中枢神经损伤,减轻神经退行性病变,降低帕金森病的发生。

Objective To investigate the relationship between blood glucose, insulin levels and the risk of Parkinson’s disease in patients with type 2 diabetes. Methods Selected 342 cases of type 2 diabetes diagnosed in the hospital from March 2019 to March 2021, of which 80 patients with Parkinson’s disease were used as the observation group, and 262 patients without Parkinson’s disease were used as the control group. Compared the blood glucose and insulin levels of the two groups of patients, and the correlation between blood glucose and insulin levels and Parkinson’s disease was analyzed. Results Compared the fasting blood glucose and insulin levels between the two groups, the fasting blood glucose of the observation group was higher than that of the control group, but the insulin level was lower than that of the control group, the difference was statistically significant(P <0.05). The incidence of Parkinson’s disease increases with increasing blood sugar levels and decreases with decreasing insulin levels. Used linear correlation analysis, the correlation analysis between the blood glucose level of patients with type2 diabetes and Parkinson’s disease, there was a high degree of positive correlation between the two(r =0.786).Correlation analysis between insulin level and Parkinson’s disease in patients with type 2 diabetes, there was a significant negative correlation between the two(r =-0.678). Conclusion Type 2 diabetes can lead to abnormal fasting blood glucose and insulin levels and increase the risk of Parkinson’s disease. Therefore, the abnormal glucose metabolism and insulin secretion of type 2 diabetes can be regulated to reduce the central nervous system damage of patients, reduce neurodegenerative diseases and reduce the occurrence of Parkinson disease.