分析硫辛酸辅以前列地尔治疗老年2型糖尿病周围神经病变的效果

Analysis on the Effect of Lipoic Acid and Prostadil in the Treatment of Elderly Type 2 Diabetic Peripheral Neuropathy

目的分析硫辛酸辅以前列地尔治疗老年2型糖尿病周围神经病变的效果。方法以2019年8月—2021年8月为研究时间,选取此时间段内该院收治的老年2型糖尿病周围神经病变患者98例进行调查。按照随机抽样分组法对其进行分组。参比组患者使用前列地尔进行治疗,研究组患者使用硫辛酸辅以前列地尔进行治疗。分析两组患者治疗前和治疗3周后的血糖水平、神经传导速度、神经功能情况、临床疗效、药物不良反应发生率。结果治疗前,两组患者的血糖水平、神经传导速度差异无统计学意义(P>0.05)。治疗3周后,研究组患者的空腹血糖水平为(7.58±1.17)mmol/L、餐后2 h血糖水平(9.16±1.98)mmol/L、糖化血红蛋白水平(6.18±1.46)%均低于参比组,差异有统计学意义(t=8.827、4.213、7.584,P<0.001);研究组患者的神经传导速度为(51.27±4.91)m/s、神经功能情况为(11.02±1.28)分均优于参比组,差异有统计学意义(t=7.796、9.626,P<0.001);研究组患者的临床疗效97.96%高于参比组,差异有统计学意义(χ^(2)=5.995,P=0.014);研究组患者的药物不良反应发生率与参比组相比差异无统计学意义(χ^(2)=0.136,P=0.712)。结论在对老年2型糖尿病周围神经病变患者进行治疗时,使用硫辛酸辅以前列地尔进行治疗能够降低患者血糖水平,改善神经传导速度,促进神经功能恢复,提高临床疗效,值得研究推广。

Objective To analyze the effect of lipoic acid combined with prostadil in the treatment of elderly type 2 diabetic peripheral neuropathy.Methods The study period was from August 2019 to August 2021.A total of 98 elderly patients with type 2 diabetic peripheral neuropathy who were admitted to the hospital during this time period were selected for investigation.They were grouped according to the random sampling grouping method.Patients in the reference group were treated with alprostadil,and patients in the study groupwere treated with lipoic acid supplemented with alprostadil.The blood glucose levels,nerve conduction velocity,nerve function,clinical efficacy,and ioncidence of adverse drug reactions of the two groups of patients before treatment and after 3 weeks of treatment were analyzed.Results Before treatment,there was no statistically significant difference in blood glucose level and nerve conduction velocity between the two groups(P>0.05).After 3 weeks of treatment,the fasting blood glucose level of the study groupwas(7.58±1.17) mmol/L,the 23 postprandial blood glucose level(9.16±1.98) mmol/L,glycosylated hemoglobin level(6.18±1.46)% was lower than the reference group,the difference was statistically significant(t=8.827,4.213,7.584,P<0.001).The nerve conduction velocity of patients in the study groupwas(51.27±4.91) m/s and the neurological function was(11.02±1.28) points better than the reference group,the difference was statistically significant(t=7.796,9.626,P<0.001).The clinical efficacy of patients in the study group was 97.96% higher than that of the reference group,and the difference was statistically significant(χ^(2)=5.995,P=0.014).There was no statistically significant difference in the incidence of adverse drug reactions between the study groupand the reference group(χ^(2)=0.136,P=0.712).Conclusion In the treatment of elderly patients with type 2 diabetic peripheral neuropathy,treatment with lipoic acid and prostadil can reduce the patient’s blood glucose level,improve nerve conduction velocity,promote nerve function recovery,and improve clinical efficacy.It is worth researching and promoting.