纤维支气管镜肺泡灌洗联合孟鲁司特治疗肺炎支原体肺炎的临床研究

Clinical Study of Bronchoscopic Alveolar Lavage Combined with Montelukast in the Treatment of Mycoplasma Pneumoniae Pneumonia

目的探究肺炎支原体肺炎患儿接受纤维支气管镜肺泡灌洗联合孟鲁司特治疗的临床应用效果。方法选取该科室2017年1月—2020年12月收治的100例肺炎支原体肺炎患儿为研究对象,并随机分成两组,其中接受纤维支气管镜肺泡灌洗治疗的50例患儿纳入对照组,基于纤维支气管镜肺泡灌洗,给予孟鲁司特治疗的50例患儿纳入观察组,记录症状消失及住院时间,检测血清炎性因子水平及肺功能水平,对比显效率。结果干预后,观察组发热、咳嗽、肺部啰音消失时间为(8.08±2.62)、(12.49±2.58)、(7.59±3.09)d、住院时间(12.22±2.81)d,显著低于对照组,差异有统计学意义(P<0.05);观察组经治疗,患儿IL-6(60.43±3.38)pg/mL、IL-8(130.35±5.14)pg/mL、CRP(2.72±0.26)mg/L,低于对照组,差异有统计学意义(P<0.05);经临床治疗,观察组、对照组显效率分别为66.00%、46.00%,两组比较差异有统计学意义(χ^(2)=4.058,P<0.05);观察组治疗后,患儿FEV1(2.42±0.71)L、FVC(2.88±0.77)L,优于对照组,差异有统计学意义(P<0.05)。结论肺炎支原体肺炎患儿接受纤维支气管镜肺泡灌洗联合孟鲁司特治疗,患儿治疗时间明显更短,进一步缓解了患儿的症状与体征,达到了良好的应用效果。

Objective To explore the clinical application effect of bronchoscopic alveolar lavage combined with montelukast in children with Mycoplasma pneumoniae pneumonia.Methods Selected 100 children with Mycoplasma pneumoniae pneumonia admitted to the department from January 2017 to December 2020 as the study subjects and randomly divided into two groups.Among them,50 children who received fiberoptic bronchoscopy alveolar lavage were included in the control group,and 50 children who were treated with montelukast based on fiberoptic bronchoscopy alveolar lavage were included in the observation group.Recorded the disappearance of symptoms and the length of stay in the hospital,detected the level of serum inflammatory factors and the level of lung function,and compared the efficiency.Results After the intervention,the disappearance time of fever,cough,and pulmonary rales in the observation group was(8.08±2.62) d,(12.49±2.58) d,(7.59±3.09) d,and hospital stay(12.22±2.81) d,significantly lower than the control group,the difference was statistically significant(P<0.05).After treatment in the observation group,IL-6(60.43±3.38) pg/mL,IL-8(130.35 ±5.14) pg/mL,and CRP(2.72±0.26) mg/L of children in the observation group were significantly lower than those in the control group,the difference was statistically significant(P<0.05).After clinical treatment,the observation group and the control group had significant efficiencies of 66.00% and 46.00% respectively,the difference was statistically significant(χ^(2)=4.058,P<0.05).After treatment in the observation group,the children with FEV1(2.42±0.71)L and FVC(2.88±0.77)L were better than those in the control group,the difference was statistically significant(P<0.05).Conclusion Children with Mycoplasma pneumoniae pneumonia receive fiberbronchoscope alveolar lavage combined with montelukast,and the treatment time is significantly shorter in children.It further relieves the symptoms and signs of the children,and achieves a good application effect.