维生素AD安全范围内采用波浪式剂量给药方法对预防婴儿维生素D缺乏病的效果分析

Analysis of the Effect of Wave-type Dosing Method on the Prevention of Vitamin D Deficiency in Infants within the Safe Range of Vitamin AD

目的研究婴儿维生素D缺乏病采用维生素AD波浪式剂量给药方法的预防效果。方法选取该院儿科2019年1月—2021年1月接受治疗的80例婴儿进行研究,采用中心数字随机法将婴儿分为甲组与乙组,各40例,分别接受传统给药与波浪式剂量给药方法,研究给药后的维生素D缺乏病症状评分、骨骼异常情况、25-(OH)与AKP异常、常见疾病患病情况、用药安全、经济性与便捷性、家属满意情况。结果治疗后,乙组婴儿维生素D缺乏病症状评分低于甲组婴儿,差异有统计学意义(P<0.05);治疗后,乙组婴儿骨骼异常情况发生率低于甲组婴儿,差异有统计学意义(χ^(2)=7.314,P=0.007);治疗后,乙组婴儿25-(OH)与AKP异常发生率低于甲组婴儿,差异有统计学意义(P<0.05);乙组婴儿常见疾病患病次数低于甲组婴儿,差异有统计学意义(P<0.05);治疗后,乙组婴儿用药安全与甲组婴儿差异无统计学意义(P>0.05);治疗后,乙组婴儿家属满意情况高于甲组婴儿,差异有统计学意义(P<0.05)。结论婴儿维生素D缺乏病预防过程中用维生素AD波浪式剂量给药方法进行治疗,能够有效预防骨骼异常情况、25-(OH)异常、AKP异常的发生,改善维生素D缺乏病症状,提高婴儿身体免疫能力,有效预防多种疾病的发生,临床应用价值高。

Objective To study the preventive effect of the wave-dosing method of vitamin AD in infants with vitamin D deficiency.Methods 80 infants from January 2019 to January 2021 in the Pediatrics Department of Nantong Hospital of Integrated Traditional Chinese and Western Medicine were selected for the study.The infants were divided into group A and group B by the central digital random method,each with 40 infants,and received traditional dosing and wave-dosing methods respectively.To study the scores of vitamin D deficiency symptoms,bone abnormalities,25-(OH) and AKP abnormalities,common diseases,medication safety,economy and convenience,and family satisfaction after administration.Results After treatment,the vitamin D deficiency symptom score of infants in group B was lower than that of infants in group A,the difference was statistically significant(P<0.05).After treatment,the incidence of skeletal abnormalities in group B infants was lower than that in group A infants,the difference was statistically significant(χ^(2)=7.314,P=0.007).After treatment,the incidence of 25-(OH) and AKP abnormalities in group B infants was lower than that of infants in group A,the difference was statistically significant(P<0.05).The number of common diseases among infants in group B was lower than that in infants in group A,the difference was statistically significant(P<0.05).After treatment,there was no statistically significant difference in medication safety between group B infants and group A infants(P>0.05).After treatment,the satisfaction of family members of group B infants was higher than that of group A infants,the difference was statistically significant(P<0.05).Conclusion During the prevention of vitamin D deficiency in infants,the wave-dose administration of vitamin AD can effectively prevent the occurrence of skeletal abnormalities,25-(OH) abnormalities,and AKP abnormalities,improve the symptoms of vitamin D deficiency,and improve the baby’s body immunity,effectively preventing the occurrence of many diseases,wiht high clinical application value.