经导管动脉灌注化疗栓塞术对结直肠癌合并肠梗阻患者的短期疗效观察

Short-term efficacy of transcatheter arterial chemoembolization in treating colorectal cancer patients with intestinal obstruction

目的:探讨经导管动脉灌注化疗栓塞术对结直肠癌致肠梗阻患者的短期治疗效果。方法:回顾性分析广西南宁市第一人民医院2017年1月至2019年12月收治的结直肠癌伴肠梗阻不能手术或不愿做手术的患者54例,按照治疗方法不同分为观察组和对照组,每组27例。对照组接受常规化疗,观察组利用经导管动脉灌注化疗并栓塞技术进行治疗。比较两组患者肠梗阻的治疗效果、血清学指标(肿瘤标志物CEA、CA125),营养学指标血清白蛋白、血红蛋白(Hb)的变化及不良反应发生情况。结果:观察组患者在出现排便、排气及腹痛腹胀症状缓解时间均短于对照组(P<0.05),且肠梗阻治疗的有效率明显高于对照组(P<0.05);治疗后观察组血清CEA、CA125明显低于对照组,血清白蛋白、Hb含量高于对照组(均P<0.05)。结论:经导管动脉灌注化疗栓塞技术靶点明确、效果迅速,是治疗结肠癌伴肠梗阻一种有效的治疗手段。

Objective:To investigate the short-term efficacy of transcatheter arterial chemoembolization in treating colorectal cancer patients with intestinal obstruction.Methods:Data of 54 colorectal cancerpatients with intestinal obstruction who could not be operated or were unwilling to be operated in our hospital from January 2017 to December 2019 were collected and retrospectively analyzed.They were divided into two groups(n=27 per group)according to different treatment methods.The patients in the control group received conventional chemotherapy,and those in the observation group received transcatheter arterial infusion chemotherapy and embolization.The therapeutic effects of intestinal obstruction,the serum indicators(tumor markers CEA,CA125,nutritional indicators serum albumin,hemoglobin),and the incidence of adverse reactions were compared.Results:The remission time of defecation,exhaust,abdominal pain and abdominal distension in the observation group was shorter than that in the control group,and the effective rate of intestinal obstruction treatment was significantly higher(P<0.05).After treatment,the serum levels of CEA and CA125 in the observation group were significantly lower than those in the control group;while the serum albumin and hemoglobin contents were higher(P<0.05).Conclusion:Transcatheter arterial infusion chemoembolization is an effective treatment for colon cancer with intestinal obstructionbecause of its clear target and rapid effect.