盐酸氨溴索灌洗联合HFNC治疗急性呼吸衰竭血气指标、氧化应激反应、舒适度改善价值研究

Effects of Ambroxol Hydrochloride Lavage combined with HFNC on Blood Gas Parameters,Oxidative Stress Response and Comfort in Acute Respiratory Failure

目的:探讨经鼻高流量鼻导管湿化氧疗(HFNC)联合盐酸氨溴索灌洗用于急性呼吸衰竭患者治疗的临床有效性。方法:选取2018年4月-2019年6月在本院诊治的急性呼吸衰竭患者68例按治疗方案分为两组,接受鼻导管常规氧疗治疗的38例患者作为对照组,接受HFNC联合盐酸氨溴索灌洗治疗的30例患者作为观察组,回顾分析患者血气指标、氧化应激反应指标改善情况及并发症等。结果:治疗后观察组PaO_(2)、SaO_(2)、OI、SOD水平均高于对照组,PaCO_(2)、Lac、MDA水平均显著低于对照组(P<0.05);治疗后1h、24h、48h观察组的NRS评分均低于对照组(P<0.05);观察组并发症总发生率显著低于对照组(P<0.05)。结论:给予急性呼吸衰竭患者HFNC联合盐酸氨溴索灌洗治疗,可有效提高患者血气指标改善效果,减轻机体氧化应激反应,提高患者舒适度,减少并发症,有助于预后改善。

Objective:To evaluate the clinical efficacy of nasal high-flow nasocatheter humidification oxygen therapy(HFNC)combined with ambroxol hydrochloride lavage in the treatment of acute respiratory failure.Methods:68 patients with acute respiratory failure diagnosed and treated in our hospital from April 2018 to June 2019 were divided into two groups,the control group was 38 patients who received routine oxygen therapy through nasal catheter,and the observation group was 30 patients who received HFNC combined with ambroxol hydrochloride lavage,the improvement of blood gas index,oxidative stress reaction index and complications were analyzed retrospectively.Results:After treatment,PaO_(2),SaO_(2),OI,SOD levels in the observation group were significantly higher than those in the control group,and PaCO_(2),Lac,MDA levels were significantly lower than those in the control group(P<0.05).The NRS scores of the observation group at 1 hour,24 hours and 48 hours after treatment were significantly lower than those of the control group(P<0.05).The total incidence of complications in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:HFNC combined with ambroxol hydrochloride lavage was administered to patients with acute aspiration failure,can effectively improve the improvement effect of blood gas index,reduce the body’s oxidative stress reaction,improve the clinical diagnosis and treatment of aspiration failure,improve the overall therapeutic effect of patients,reduce complications,and help improve prognosis.