慢加急性肝衰竭:定义、诊断与发病机制

Acute-on-chronic liver failure:definition,diagnosis,and pathogenesis

慢加急性肝衰竭(ACLF)是一种在慢性肝病基础上出现的急性肝功能恶化,伴随肝脏和肝外器官衰竭的高病死率复杂综合征,内科综合治疗的短期病死率高达50%~90%。现对目前常见的ACLF定义和诊断标准、预警预测模型和发病机制等进行总结。

Acute-on-chronic liver failure(ACLF)is a form of complex syndrome with acute deterioration of liver function that occurs on the basis of chronic liver disease,and is accompanied by hepatic and extrahepatic organ failure with high mortality rate.The short-term mortality rate of comprehensive internal medicine treatment is as high as 50%-90%.This paper summarizes the current common definitions and diagnostic criteria,early-warning prediction models,and pathogenesis of ACLF.