摘要
疫苗的免疫持久性评价方法包括直接评价、间接评价以及模型预测、Meta分析等方法。直接评价通过评价疫苗对所预防疾病发病和(或)感染的保护作用来评价疫苗的免疫持久性,是疫苗的免疫持久性评价的金标准。通过免疫学替代指标间接评价疫苗的免疫持久性,在实践中应用更为广泛。此外,数学模型、Meta分析等方法也可用于疫苗的免疫持久性评价。结合具体情况选择恰当的评价方法分析疫苗的免疫持久性,对完善疫苗免疫策略具有重要意义。
The evaluation methods of immune persistence include direct evaluation,indirect evaluation,model prediction,and meta-analysis and so on.Direct evaluation is the gold standard for evaluating the immune persistence of vaccines by quantifying the protective effect of vaccines on the onset and(or)infection of preventable diseases.Indirect evaluation of immune persistence by immunological surrogate indicators is more widely used in practice.In addition,mathematical models and meta-analysis can also be used to evaluate the immune persistence of vaccines.It is of great significance to select the appropriate evaluation method to analyze the immune persistence of the vaccine according to the specific situation.
作者
陈颖
周弘璐
赵玉良
汪萱怡
Chen Ying;Zhou Honglu;Zhao Yuliang;Wang Xuanyi(Vaccine Clinical Research institute of Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang 050021,China;The Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China;MoE&NHC Key Laboratory of Medical Molecular Virology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Children′s Hospital of Fudan University,Shanghai 201102,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2022年第2期212-217,共6页
Chinese Journal of Preventive Medicine
关键词
疫苗
评价研究
免疫持久性
Vaccine
Evaluation studies
Immune persistence
