余甘子及其活性成分肝保护作用及机制的研究进展

Research progress on hepatoprotective effect and mechanism of Phyllanthus emblica and its active components

余甘子来源于余甘子Phyllanthus emblica的干燥成熟果实,是我国重要的药食同源品种,具有抗炎、抗氧化、抗肿瘤和免疫调节等广泛的生物活性。通过对余甘子提取物及其所含没食子酸、鞣花酸及柯里拉京等活性成分的药理作用进行总结,发现其对肝损伤、病毒性肝炎、非酒精性脂肪肝、肝纤维化及肝癌等具有治疗作用,主要通过抑制脂质过氧化、降低炎症反应、抗肝细胞凋亡、调节脂质代谢、维持肝星状细胞稳态及促肝癌细胞凋亡等发挥肝保护作用。对余甘子及其单体活性成分治疗肝脏疾病的药理作用及其机制进行归纳分析,以期为其在防治肝脏疾病中的深入研究以及开发应用提供参考依据。

Yuganzi(Phylianthi Fructus) is derived from dried ripe fruits of Phyllanthus emblica, and is an important medicinal and food homologous variety in China, which possessed a wide range of biological activities including anti-inflammatory, anti-oxidant,anti-tumor and immune regulation. By summarizing the pharmacological effects of P. emblica extracts and its active ingredients such as gallic acid, ellagic acid and corilagin, it is indicated that the extracts and monomer components have therapeutic effects on liver damage, viral hepatitis, non-alcoholic fatty liver, liver fibrosis and liver cancer mainly through inhibiting lipid peroxidation, reducing inflammation, anti-apoptosis of hepatocytes, regulating lipid metabolism, maintaining the homeostasis of hepatic stellate cells and promoting apoptosis of hepatoma cells. Hepatoprotective effects and related mechanisms of P. emblica and its components are summarized and analyzed in this paper, in order to provide a reference for further research and development of P. emblica in prevention and treatment of liver diseases.