特应性皮炎患儿临床特征及血清Apo A1、25(OH)D、EDN水平变化

Clinical characteristics of children with atopic dermatitis and change in serum levels of Apo A1,25(OH)D and EDN

目的探讨特应性皮炎(AD)患儿临床特征及血清载脂蛋白A1(Apo A1)、25羟基维生素D[25(OH)D]、嗜酸性粒细胞衍生神经毒素(EDN)水平变化。方法回顾性选取2016年1月至2019年12月株洲市中心医院就诊的200例AD患儿为AD组,100例健康体检儿童为对照组。分析AD患儿临床特征,对比两组血清Apo A1、25(OH)D、EDN水平差异,探讨血清Apo A1、25(OH)D、EDN水平与AD病情严重程度的关系。结果200例AD患儿男女构成比为1.41∶1,发病年龄<3个月占比最高[64.50%(129/200)],检测出吸入性过敏原118例(59.00%),食入性过敏原82例(41.00%)。AD组患儿血清Apo A1、EDN水平均高于对照组(均P<0.05),而血清25(OH)D水平则明显低于对照组(P<0.05)。随着病情的加重,AD患儿血清Apo A1、EDN水平逐渐升高,而血清25(OH)D则呈明显降低趋势(均P<0.05)。AD患儿AD严重程度评分与血清Apo A1、EDN水平呈正相关(均P<0.05),与血清25(OH)D水平呈负相关(P<0.05)。结论Apo A1、25(OH)D、EDN参与小儿AD的发病过程,其血清表达水平与AD病情严重程度密切相关。

Objective To investigate the clinical characteristics of children with atopic dermatitis(AD)and the changes in serum levels of apolipoprotein A1(Apo A1),25-hydroxyvitamin D[25(OH)D]and eosinophil derived neurotoxin(EDN).Methods 200 children with AD treated in Zhuzhou Central Hospital from January 2016 to December 2019 were selected retrospectively as AD group and 100 healthy children as control group.The clinical characteristics of children with AD were analyzed,and the differences in serum Apo A1,25(OH)D and EDN levels between two groups were compared.The relationships between serum Apo A1,25(OH)D,EDN levels and severity of AD were explored.Results The male to female composition ratio of 200 AD patients was 1.41∶1,and the age of onset<3 months was the highest(64.50%).Inhalation allergens were detected in 118 cases(59.00%)and ingestion allergens in 82 cases(41.00%).The levels of Apo A1 and EDN in AD group were significantly higher than those in control group,while the level of 25(OH)D was significantly lower than that in control group(P<0.05).With the aggravation of the disease,the serum Apo A1 and EDN levels in AD children increased gradually,while the serum 25(OH)D level decreased significantly(all P<0.05).Severity Scoring of Atopic Dermatitis(SCORAD)was positively correlated with Apo A1 and EDN levels(P<0.05),and was negatively correlated with 25(OH)D level(all P<0.05).Conclusions Apo A1,25(OH)D and EDN are involved in the pathogenesis of AD in children,and their serum levels are closely related to the severity of AD.