肿瘤蛋白D52在胰腺癌组织中的表达及其临床意义

Expression of tumor protein D52 in pancreatic cancer and its clinical significance

目的探讨胰腺癌中肿瘤蛋白D52(tumor protein D52,TPD52)的表达与其临床病理特征及预后的关系。方法回顾性分析2015年6月至2020年6月于河北省沧州市中心医院接受根治性手术治疗并病理确诊的129例胰腺导管腺癌患者临床病例资料,应用免疫组织化学技术检测癌组织及癌旁组织中TPD52表达水平,采用χ^(2)检验或Fisher确切概率法分析两者表达差异及与患者临床病理特征的关系;采用Kaplan-Meier法和Log-rank检验进行生存时间分析;采用Cox比例风险回归模型分析患者预后影响因素。结果TPD52在胰腺癌组织中表达水平高于癌旁组织(χ^(2)=22.389,P<0.001),其表达与患者的TNM分期(χ^(2)=4.178,P=0.041)、神经侵犯(χ^(2)=8.499,P=0.004)及组织分化程度(χ^(2)=12.262,P=0.002)明显相关。TPD52高表达患者术后mDFS及mOS分别为8.3、16.6个月,TPD52低表达患者则分别为18.7、24.6个月。TPD52表达与胰腺癌患者术后DFS(Log-rank χ^(2)=11.460,P=0.001)及OS(Log-rank χ^(2)=11.450,P=0.001)相关,TPD52表达水平高则DFS及OS均缩短。TPD52高表达(P<0.05)是影响胰腺癌术后DFS及OS的独立因素。结论 TPD52有助于胰腺癌患者预后评估,TPD52高表达者预后较差。

objective To investigate the expression of tumor protein D52 (TPD52) in pancreatic cancer tissues and its correlation with patients’clinicopathological characteristics and prognosis.Methods Clinicopathological data of 129 patients with pancreatic ductal adenocarcinoma who received radical surgical treatment and were pathologically confirmed from Jun.2015 to Jun.2020 in Cangzhou Central Hospital were retrospectively analyzed.The expression of TPD52 was evaluated by immunohistochemistry.The relationship between TPD52and clinicopathological factors was analyzed by χ^(2) test or Fisher’s exact test.Kaplan-Meier method and Log-rank test were performed to analyze the survival time.Cox proportional risk regression model was used to analyze prognostic factors.Results The expression level of TPD52 in pancreatic cancer tissues was higher than that in adjacent tissues (χ^(2)22.389,P<0.001),and its expression was significantly correlated with TNM staging (χ^(2)4.178,P=0.041),nerve invasion (χ^(2)8.499,P=0.004) and tissue differentiation degree (χ^(2)12.262,P=0.002).The m DFS and m OS were 8.3 months and 16.6 months in patients with high expression of TPD52,while they were18.7 months and 24.6 months in patients with low expression of TPD52.The expression of TPD52 was correlated with postoperative DFS (Log-rankχ^(2)11.460,P=0.001) and OS (Log-rankχ^(2)11.450,P=0.001),and DFS and OS were shortened if the expression level of TPD52 was high.High expression of TPD52 (P<0.05) was an independent factor affecting postoperative DFS and OS in patients with pancreatic cancer.Conclusion TPD52 is highly expressed in pancreatic cancer,which contributes to the prognosis assessment of patients with pancreatic cancer.The prognosis is poor in patients with high expression of TPD52.