醛固酮受体拮抗剂在难治性高血压中的临床研究进展

Clinical Research Progress of Aldosterone Receptor Antagonists in Resistant Hypertension

难治性高血压病因复杂,水钠潴留、肾素-血管紧张素-醛固酮系统激活、交感神经系统活性增强是其重要的发病机制。近年的研究发现,在难治性高血压基础治疗上添加小剂量醛固酮受体拮抗剂能有效控制血压,保护靶器官,改善预后。现就醛固酮受体拮抗剂在难治性高血压中的临床研究作一综述。

The etiology of resistant hypertension is complex,and its important pathogenesis is water and sodium retention,activation of the renin-angiotensin-aldosterone system,and enhanced sympathetic nervous system activity.In recent years,it has been found that adding low-dose aldosterone receptor antagonist to the basic treatment of resistant hypertension can effectively control blood pressure,protect target organs and improve prognosis.This article reviews the clinical research of aldosterone receptor antagonists in resistant hypertension.