普瑞巴林联合泼尼松对带状疱疹后遗神经痛患者睡眠质量与免疫功能的影响

Effects of Pregabalin Combined with Prednisone on Sleep Quality and Immune Function in Patients with Postherpetic Neuralgia

目的分析普瑞巴林联合泼尼松治疗带状疱疹后遗神经痛患者的疗效,并分析对患者睡眠治疗与免疫功能的影响。方法方便选取2020年1月—2021年7月该院78例带状疱疹后遗神经痛患者为研究对象,应用单盲分组方式对患者进行分组,每组39例,常规组单纯应用普瑞巴林对患者展开治疗,联合组在常规组方法基础上增加泼尼松对患者进行治疗,对两组患者临床疗效、睡眠质量、疼痛程度以及免疫功能进行对比。结果联合组患者临床治疗有效率为92.3%,显著高于常规组,差异有统计学意义(χ^(2)=5.571,P=0.018);联合组VAS与PSQI评分分别为(1.83±0.92)分、(3.01±1.27)分,显著低于常规组,差异有统计学意义(t=4.320、11.037,P<0.001);联合组患者CD3^(+)、CD4^(+)、CD8^(+)以及CD4^(+)/CD8^(+)分别为(62.92±5.54)%、(39.33±4.65)%、(24.20±1.41)%、(1.45±0.21),均优于常规组,差异有统计学意义(t=9.236、11.207、10.129、7.396,P<0.001)。结论普瑞巴林联合泼尼松的方案具有显著临床应用价值,能够改善带状疱疹后遗神经痛患者的睡眠质量与疼痛程度,并有助于提高患者免疫功能,促进患者康复。

Objective Analyze the efficacy of pregabalin combined with prednisone in the treatment of patients with post-herpetic neuralgia,and analyze the effects on patients'sleep therapy and immune function.Methods 78 patients with postherpetic neuralgia in the hospital from January 2020 to July 2021 were conveniently selected as the research object.The patients were divided into two groups by single blind grouping,with 39 cases in each group.The conventional group was treated with pregabalin alone,and the combined group was treated with prednisone on the basis of the conventional group method.The clinical efficacy,sleep quality,pain degree and immune function of the two groups of patients were compared.Results The clinical treatment effective rate of patients in the combined group was 92.3%was significantly higher than that in the conventional group,and the difference was statistically significant(χ^(2)=5.571,P=0.018);the VAS and PSQI scores of the combined group were(1.83±0.92)points and(3.01±1.27)points,respectively,was significantly lower than that of the conventional group,and the difference was statistically significant(t=4.320,11.037,P<0.001);the CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)of the combined group were(62.92±5.54)%,(39.33±4.65)%,(24.20±1.41)%,(1.45±0.21),respectively,were better than those of the conventional group,and the difference was statistically significant(t=9.236,11.207,10.129,7.396,P<0.001).Conclusion The combination of pregabalin and prednisone has significant clinical application value,which can improve the sleep quality and pain degree of patients with postherpetic neuralgia,and help improve the immune function of the patients and promote the recovery of the patients.