摘要
Cancer patients are at increased risk for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and mortality.Like other viruses in the SARS family,SARS-CoV-2 employs two host proteins,angiotensin-converting enzyme 2(ACE2)and transmembrane serine protease 2(TMPRSS2),for viral entry.1 Recent studies showed that many of the host proteins identified as potential targets for developing COVID therapies are dysregulated in cancer,2 prompting us to investigate whether human cancer cells are susceptible to SARS-CoV-2 infection,and whether chemotherapy could modulate a cancer patient's risk for infection.
基金
This project was supported by grants from the National Institutes of Health(No.R01 CA236356 and R01 CA213293)to Wei Xu
University of Wisconsin Carbone Cancer Center Support Grant(No.P30 CA014520)
Dr.Shengjie Zhang received partial salary support from the National Natural Science Foundation of China(No.81502603).
