浙江地区妊娠中晚期孕妇血脂参考区间的建立

Establishment of Reference Interval for Blood Lipids of Pregnant Women in the Middle and Late Stages of Pregnancy in Zhejiang

目的建立浙江地区妊娠中晚期健康孕妇的血脂参考区间。方法选择2020年1—12月浙江大学医学院附属妇产科医院健康妊娠妇女590名作为研究组,健康非妊娠妇女190名作为对照组,检测所有研究对象TC、TG、LDL-C和HDL-C水平。结果研究组孕中期妇女TC,TG,LDL-C,HDL-C水平分别为5.73(5.04~6.41)、2.00(1.62~2.48)、3.22(2.57~3.75)、1.68(1.49~1.94)mmol/L,较对照组非妊娠妇女明显升高,差异有统计学意义(P<0.05);研究组孕晚期妇女TC,TG,LDL-C,HDL-C水平分别为5.96(5.04~6.84)、2.67(2.10~3.59)、3.33(2.61~3.97)、1.48(1.28~1.78)mmol/L,较对照组非妊娠妇女明显升高,差异有统计学意义(P<0.05);与研究组孕中期妇女比较,研究组孕晚期妇女TC和TG水平明显升高,HDL-C水平明显降低,差异有统计学意义(P<0.05)。浙江地区健康孕妇TC、TG、LDL-C和HDL-C水平的95%参考区间分别为:妊娠中期:3.70~8.20、1.07~3.69、1.65~5.40、0.99~2.43 mmol/L;妊娠晚期:3.88~9.02、1.25~7.24、1.72~5.95、0.88~2.31 mmol/L。结论非孕人群的血脂参考区间不适用于孕妇人群,建立孕妇人群血脂特异性参考区间具有重要价值。

Objective To establish a reference interval for blood lipids of healthy pregnant women in the middle and late stages of pregnancy in Zhejiang Province.Methods From January to December 2020,590 healthy pregnant women in the Obstetrics and Gynecology Hospital of Zhejiang University School of Medicine were selected as the study group,and 190 healthy non-pregnant women as the control group.All research objects were tested for TC,TG,LDL-C and HDL-C levels.Results The levels of TC,TG,LDL-C and HDL-C in the second trimester women were in the study group 5.73(5.04-6.41)mmol/L,2.00(1.62-2.48)mmol/L,3.22(2.57-3.75)mmol/L,1.68(1.49-1.94)mmol/L,compared with non-pregnant women in the control group,it was significantly higher,and the difference was statistically significant(P<0.05);women in the third trimester in the study group of TC,TG,LDL-C and HDL-C were 5.96(5.04-6.84)mmol/L,2.67(2.10-3.59)mmol/L,3.33(2.61-3.97)mmol/L,1.48(1.28-1.78)mmol/L,compared with non-pregnant women,it was significantly higher,and the difference was statistically significant(P<0.05);compared with women in the second trimester in the study group,the levels of TC and TG women in the third trimester were significantly increased,HDL-C level was significantly reduced,the difference was statistically significant(P<0.05).Healthy pregnant women in Zhejiang area TC,TG,the 95%reference intervals for LDL-C and HDL-C levels were:the second trimester:3.70-8.20 mmol/L,1.07-3.69 mmol/L,1.65-5.40 mmol/L and 0.99-2.43 mmol/L;late pregnancy:3.88-9.02 mmol/L,1.25-7.24 mmol/L,1.72-5.95 mmol/L and 0.88-2.31 mmol/L.Conclusion The blood lipid reference interval for non-pregnant people is not suitable for pregnant women,and the specific reference interval for blood lipids for pregnant women is established Has important value.