肺结核患者中丙型肝炎分布特征及与肝功能损害的相关性

Distribution characteristics of hepatitis C in patients with pulmonary tuberculosis and its correlation with liver function damage

目的:分析肺结核患者中丙型肝炎分布特征及其与肝功能损害的关联性。方法:选择收治的1310例肺结核患者作为研究对象,对其行肝功能检测,根据检测结果将其分为合并丙型肝炎组和未合并丙型肝炎组,对比合并丙型肝炎组和未合并丙型肝炎组肝功能损害发生率,并分析引发患者出现肝功能损害的危险因素。结果:共有152例患者发生丙型肝炎,丙型肝炎发生率为11.60%。合并丙型肝炎组患者性别为男性、年龄段为青年的发生率显著高于未合并丙型肝炎组,两组比较差异有统计学意义(P<0.05)。两组居住地比较差异无统计学意义(P>0.05)。肺结核患者中发生肝功能损害组男性、合并丙型肝炎、饮酒的例数显著高于未发生肝功能损害组,两组比较,差异有统计学意义(P<0.05)。两组患者年龄段、治疗情况比较差异无统计学意义(P>0.05);Logistic回归模型分析结果显示性别、合并丙型肝炎、饮酒均是引发肝功能损害发生的独立危险因素。结论:肺结核患者中合并丙型肝炎患者肝功能损害发生率显著高于未合并丙型肝炎者,除此之外肝功能损害的发生与患者性别、饮酒也有关。

Objective To analyze the distribution characteristics of hepatitis C in patients with pulmonary tuberculosis and its correlation with liver function damage.Method 1310 cases of pulmonary tuberculosis patients in our hospital were selected as the research object,and their liver function was tested.According to the test results,they were divided into the combined hepatitis C group and the non combined hepatitis C group,the incidence of liver function damage in the combined hepatitis C group and the non combined hepatitis C group was compared,and the risk of liver function damage was analyzed factor.Results A total of 152 patients developed hepatitis C.The incidence rate of hepatitis C was 11.60%.The rate of male sex and young age in the group with hepatitis C was significantly higher than that in the group without hepatitis C.The comparison between the two groups was statistically significant(P<0.05);There was no significant difference between the two groups of patients in the place of residence(P>0.05).The rate of males in the pulmonary tuberculosis patients with liver damage,the rate of hepatitis C,and the rate of alcohol consumption were significantly higher than those without liver function in the damage group,the comparison between the two groups was statistically significant(P<0.05).There was no significant difference in the age group and treatment status of the two groups(P>0.05);Logistic regression analysis showed that gender,hepatitis C and alcohol consumption were independent risk factors for liver function damage.Conclusion The incidence of liver function damage in tuberculosis patients with hepatitis C is significantly higher than that in patients without hepatitis C.In addition,the incidence of liver function damage is also related to gender and drinking.