摘要
目的系统评价中国健康人群抗百日咳毒素IgG抗体(PT-IgG)水平。方法检索2010年1月1日至2021年9月30日有关中国健康人群血清PT-IgG研究文献,系统分析PT-IgG检测阳性界值、人群PT-IgG阳性率和百日咳近期/急性感染率。结果共纳入30篇研究文献,包括16篇中文和14篇英文文献。所有研究采用ELISA法检测PT-IgG,其中18篇(60%)以PT-IgG≥40IU/mL为抗体阳性界值;全人群PT-IgG抗体阳性率在2.0%-33.3%之间,估计百日咳近期/急性感染率为3390/10万-10852/10万。结论中国健康人群PT-IgG抗体阳性率不高,存在较高的感染风险;建议统一检测标准并加强百日咳监测。
Objective To systematically review IgG antibody levels against pertussis toxin(PT-IgG)in healthy populations of China.Methods We retrieved literatures on PT-IgG levels of healthy Chinese populations published between January 1,2010 and September 30,2021 for a systematic review of the positivity cutoff level of PT-IgG,the positivity rate of PT-IgG,and the recent/acute pertussis infection rate.Results A total of 30 studies were reviewed,including 16 written in Chinese and 14 in English.All studies used ELISA to test for PT-IgG;18(60%)used≥40 IU/mL as the PT-IgG positivity level.The PT-IgG positivity rate in whole populations ranged from 2.0%to 33.3%.Estimated recent/acute pertussis infection rates ranged from 3390 per 100000 population to 10852 per 100000 population.Conclusions PT-IgG antibody positivity was not high in healthy Chinese populations,indicating a high risk for pertussis.We recommend developing a unified test standard and strengthening pertussis surveillance.
作者
朱瑶
何寒青
唐学雯
周洋
Zhu Yao;He Hanqing;Tang Xuewen;Zhou Yang(Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,Zhejiang,China)
出处
《中国疫苗和免疫》
CSCD
北大核心
2022年第1期115-120,共6页
Chinese Journal of Vaccines and Immunization
基金
浙江省疾病预防控制中心2021年疾控科技英才孵育项目。
