吲哚氮杂环作为自由基受体在串联环化反应中的研究进展

Research Progress in Radical Cascade Reaction Using Nitrogen Heterocycle in Indoles as Radical Acceptors

含吲哚骨架衍生物因其具有多样的生物活性,广泛应用于生物活性分子的合成与修饰,特别是在药物化学、农药化学领域中.近年来,高效的吲哚环合成与后官能化反应已成为热门的研究主题,例如吲哚的不对称去芳构化反应构建螺环衍生物.不饱和烃的自由基串联反应一直是有机化学的一个重要研究分支,含吲哚母体的不饱和烃串联环化反应已经成为吲哚骨架修饰的一种重要途径.因此,综述了吲哚骨架中氮杂环作为自由基受体在不饱和烃串联环化反应中的研究进展,并对反应设计、机理研究、研究展望等给予评述.

Indole skeleton has been widely utilized in the synthesis and late-stage modification of biologically active compounds,especially in the fields of medicines and pesticides.In recent years,constructing spiro compounds by asymmetric dearomatization of indoles has become extremely promising.Meanwhile,the radical tandem reaction of unsaturated bonds has been a significant branch of organic chemistry,and this methodology has become a crucial approach to modify the indole skeleton.Therefore,the recent progress in the field of radical cascade reaction of unsaturated hydrocarbon using nitrogen heterocycle in indoles as radical acceptors is summarized.Besides,the reaction design,mechanism and prospects of this field are also discussed.